Evidence map›Paper›PMID 28882021›Full record

ArticleCancer research and treatment2018

Sarcopenia Predicts Prognosis in Patients with Newly Diagnosed Hepatocellular Carcinoma, Independent of Tumor Stage and Liver Function.

Yeonjung Ha, Daejung Kim, Seungbong Han, Young Eun Chon, Yun Bin Lee, Mi Na Kim, Joo Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 9 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 9 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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  9. The egyptian clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yeonjung HaDepartment of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Daejung KimDepartment of Radiology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Seungbong HanDepartment of Applied Statistics, Gachon University, Seongnam, Korea.
Young Eun ChonDepartment of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Yun Bin LeeDepartment of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Mi Na KimDepartment of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Joo Ho LeeDepartment of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Hana ParkDepartment of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Kyu Sung RimDepartment of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Seong Gyu HwangDepartment of Hepatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
CHA University · KRCHA University Bundang Medical Center · KRGachon University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to demonstrate the prognostic significance of changes in body composition in patients with newly diagnosed hepatocellular carcinoma (HCC). MATERIALS AND

methodsPatients (n=178) newly diagnosed with HCC participated in the study between 2007 and 2012. Areas of skeletal muscle and abdominal fat were directly measured using a three-dimensional workstation. Cox proportional-hazards modes were used to estimate the effect of baseline variables on overall survival. The inverse probability of treatmentweighting (IPTW) method was used to minimize confounding bias.

resultsCutoff values for sarcopenia, obtained from receiver-operating characteristic curves, were defined as skeletal muscle index at the third lumbar vertebra of ≤ 45.8 cm/m2 for males and ≤ 43.0 cm/m2 for females. Sarcopenia patients were older, more likely to be female, and had lower body mass index. Univariable analysis showed that the presence of sarcopenia and visceral to subcutaneous fat area ratio (VSR) were significantly associatedwith prognosis. The multivariable analyses revealed that VSR was predictive of overall survival. However, in the multivariable Cox model adjusted by IPTW, sarcopenia, not VSR, were associated with overall survival.

conclusionThe presence of sarcopenia at HCC diagnosis is independently associated with survival.

Indexed as

Abdominal FatAgedCarcinoma, HepatocellularFemaleHumansLiver NeoplasmsMaleMiddle AgedMuscle, SkeletalNeoplasm StagingPrognosisRetrospective StudiesROC CurveSarcopeniaSurvival AnalysisTomography, X-Ray ComputedHepatocellular carcinomaOverall survivalPrognosisSarcopeniaVisceral fat

Identifiers

PMID28882021
PMCPMC6056958
OpenAlexW2752903877

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.