ArticleOncotarget2017
OGTT 1h serum C-peptide to plasma glucose concentration ratio is more related to beta cell function and diabetes mellitus.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Marginal Impact of Brown SeaweedMarine drugs · 2022Trial
- Utility of the random C-peptide and random C-peptide index at diagnosis as a predictor of disease type and long-term insulin secretory capacity in children with diabetes mellitus.Endocrine journal · 2025Article
- Comprehensive validation of fasting-based and oral glucose tolerance test-based indices of insulin secretion against gold standard measures.BMJ open diabetes research & care · 2022Article
- OGTT 2-hour serum C-peptide index as a predictor of post-transplant diabetes mellitus in kidney transplant recipients.Annals of translational medicine · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo clarify the association between C-peptide index and pancreatic beta cell function and diabetes. MATERIALS AND
methodsWe carried out a retrospective analysis of 1021 patients aged 27 to 80 without diabetes from January 2012 to January 2016. All subjects underwent a 75-g oral glucose tolerance test. Blood samples were drawn at 0, 30, 60, 120 and 180 min after the glucose load. Plasma glucose concentrations, serum insulin levels, C-peptide levels, hemoglobin A1c (HbA1c), and other biochemical indicators were determined. C-peptide index was calculated as the ratio of C-peptide to plasma glucose. Disposition index was calculated as the result of the insulin sensitivity × insulin secretion. Area under the receiver operating characteristic curve was used to compare the diagnostic ability of C-peptide index for type 2 diabetes.
resultsC-peptide index 1h was the most related one to disposition index (
conclusionC-peptide index after oral glucose ingestion may reflect the maximal β-cell function and is more related to diabetes. C-peptide index 1h is the most relevant one.
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