Evidence map›Paper›PMID 28881655›Full record

ArticleOncotarget2017

DNA hypomethylation of CBS promoter induced by folate deficiency is a potential noninvasive circulating biomarker for colorectal adenocarcinomas.

Geng Xue, Chao-Jing Lu, Shu-Jun Pan, Yin-Ling Zhang, Hui Miao, Shi Shan, Xiao-Ting Zhu, Yi Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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  7. Reprogramming of serine, glycine and one-carbon metabolism in cancer.Biochimica et biophysica acta. Molecular basis of disease · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Association between Promoter Methylation of Gene ERCC3 and Benzene Hematotoxicity.International journal of environmental research and public health · 2017
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Geng Xue *Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.
Chao-Jing Lu *Department of Thoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Shu-Jun Pan *Department of Medical Administration, Hangzhou Sanatorium of People's Liberation Army, Hangzhou 310007, China.
Yin-Ling ZhangDepartment of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.
Hui MiaoDepartment of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.
Shi ShanDepartment of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.
Xiao-Ting ZhuDepartment of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.
Yi ZhangDepartment of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China.
Second Military Medical University · CNHangzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant DNA methylation patterns, which induced by folate deficiency, play important roles in tumorigenesis of colorectal cancer (CRC). Some DNA methylation alterations can also be detected in cell-free DNA (cfDNA) of patients' plasma, making cfDNA an ideal noninvasive circulating biomarker. However, exact DNA methylation alterations induced by folate deficiency in tumorigenesis of CRC and exact potential circulating cfDNA methylation biomarker are still unclear. Therefore, DNA methylation patterns of the normal human colon mucosal epithelial cell line (NCM460), cultured with normal or low folate content, were screened and the DNA hypomethylation of cystathionine-beta-synthase (CBS) promoter was further validated

Indexed as

CBScell-free DNAcolorectal cancerDNA methylationfolate

Identifiers

PMID28881655
PMCPMC5584256
OpenAlexW2616673155

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.