Evidence map›Paper›PMID 28881605›Full record

ArticleOncotarget2017

Low PCA3 expression is a marker of poor differentiation in localized prostate tumors: exploratory analysis from 12,076 patients.

Mohammed Alshalalfa, Gerald W Verhaegh, Ewan A Gibb, Maria Santiago-Jiménez, Nicholas Erho, Jennifer Jordan, Kasra Yousefi, Lucia L C Lam, Tyler Kolisnik, Jijumon Chelissery and 10 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Long non-coding RNA in prostate cancer.American journal of clinical and experimental urology · 2022
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. The long non-coding RNAOncotarget · 2019
    Article
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  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 3 countries.

Mohammed AlshalalfaGenomeDx Biosciences Inc., Vancouver, BC, Canada.
Gerald W VerhaeghDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Ewan A GibbGenomeDx Biosciences Inc., Vancouver, BC, Canada.
Maria Santiago-JiménezGenomeDx Biosciences Inc., Vancouver, BC, Canada.
Nicholas ErhoGenomeDx Biosciences Inc., Vancouver, BC, Canada.
Jennifer JordanGenomeDx Biosciences Inc., Vancouver, BC, Canada.
Kasra YousefiGenomeDx Biosciences Inc., Vancouver, BC, Canada.
Lucia L C LamGenomeDx Biosciences Inc., Vancouver, BC, Canada.
Tyler KolisnikGenomeDx Biosciences Inc., Vancouver, BC, Canada.
Jijumon ChelisseryGenomeDx Biosciences Inc., Vancouver, BC, Canada.
Roland SeilerGenomeDx Biosciences Inc., Vancouver, BC, Canada.
Ashley E RossJames Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA.
R Jeffrey KarnesDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Edward M SchaefferDepartment of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Tamara T LotanDepartment of Pathology and Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Robert B DenSidney Kimmel Cancer Centre, Thomas Jefferson University, Philadelphia, PA, USA.
Stephen J FreedlandDepartment of Surgery, Division of Urology, Center of Integrated Research on Cancer and Lifestyle, Samuel Oschin Comprehensive Cancer Center, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Elai DavicioniGenomeDx Biosciences Inc., Vancouver, BC, Canada.
Eric A KleinGlickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Jack A SchalkenDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Genome British Columbia · CACedars-Sinai Medical Center · USCleveland Clinic · USJohns Hopkins Hospital · USJohns Hopkins Medicine · USMayo Clinic in Arizona · USNorthwestern University · USRadboud University Medical Center · NLRadboud University Nijmegen · NLThomas Jefferson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate cancer antigen 3 (

resultsMATERIALS AND

methodsA total of 1,694 expression profiles from biopsy and 10,382 from RP patients with high risk tumors were obtained from the Decipher Genomic Resource Information Database (GRIDTM)prostate cancer database. The primary clinical endpoint was distant metastasis-free survival for RP and high Gleason grade for biopsy. Logistic regression analyses and Cox proportional hazards models were used to evaluate the association of

conclusionsThere is high prevalence of high grade tumors with low

Indexed as

initial biopsyPCA3prognosisprostate cancerunder-diagnosis

Identifiers

PMID28881605
PMCPMC5584206
OpenAlexW2586802561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.