Evidence map›Paper›PMID 28881568›Full record

ArticleOncotarget2017

Modulation of estrogen related receptor alpha activity by the kinesin KIF17.

Am Pramodh Bandara Seneviratne, Zeynep Turan, Aurelie Hermant, Patrick Lecine, William O Smith, Jean-Paul Borg, Fanny Jaulin, Geri Kreitzer

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Am Pramodh Bandara SeneviratneDepartment of Molecular, Cellular & Biomedical Sciences, The City University of New York School of Medicine, New York, NY, USA.
Zeynep TuranDepartment of Cell and Developmental Biology, Weill Medical College, Cornell University, New York, NY, USA.
Aurelie HermantCentre de Recherche en Cancérologie de Marseille, Aix Marseille Univ UM105, Institut Paoli-Calmettes, UMR7258 CNRS, U1068 INSERM, Cell Polarity, Cell Signalling and Cancer, Equipe labellisée Ligue Contre le Cancer, Marseille, France.
Patrick LecineCentre de Recherche en Cancérologie de Marseille, Aix Marseille Univ UM105, Institut Paoli-Calmettes, UMR7258 CNRS, U1068 INSERM, Cell Polarity, Cell Signalling and Cancer, Equipe labellisée Ligue Contre le Cancer, Marseille, France.
William O SmithDepartment of Cell and Developmental Biology, Weill Medical College, Cornell University, New York, NY, USA.
Jean-Paul BorgCentre de Recherche en Cancérologie de Marseille, Aix Marseille Univ UM105, Institut Paoli-Calmettes, UMR7258 CNRS, U1068 INSERM, Cell Polarity, Cell Signalling and Cancer, Equipe labellisée Ligue Contre le Cancer, Marseille, France.
Fanny JaulinDepartment of Cell and Developmental Biology, Weill Medical College, Cornell University, New York, NY, USA.
Geri KreitzerDepartment of Molecular, Cellular & Biomedical Sciences, The City University of New York School of Medicine, New York, NY, USA.
Cornell University · USCentre National de la Recherche Scientifique · FRCentre de Recherche en Cancérologie de Marseille · FRCity University of New York · USInstitut Gustave Roussy · FR

Funding

Kinesin function and regulation during epithelial polarizationR01GM087575 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KREITZER, GERI E · 2010 to 2014
$1.9M
NIGMS NIH HHS R01 GM087575
6 · The paper itself

Abstract

Estrogen-related receptor alpha (ERR1) is an orphan nuclear receptor that can bind transcriptional co-activators constitutively. ERR1 expression correlates with poor patient outcomes in breast cancer, heightening interest in this nuclear receptor as a therapeutic target. Because ERR1 has no known regulatory ligand, a major challenge in targeting its activity is to find cellular or synthetic modulators of its function. We identified an interaction between ERR1 and KIF17, a kinesin-2 family microtubule motor, in a yeast-2-hybrid screen. We confirmed the interaction using

Indexed as

breast cancerepithelialestrogen related receptor alphakinesintranscription

Identifiers

PMID28881568
PMCPMC5584137
OpenAlexW2619535539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.