Evidence map›Paper›PMID 28881444›Full record

ArticleHippocampus2017

GABAergic inhibition gates excitatory LTP in perirhinal cortex.

Vibhakar C Kotak, Ana Mirallave, Todd M Mowery, Dan H Sanes

Open access · greenAbstract read
In one paragraph

Article in Hippocampus, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Vibhakar C KotakCenter for Neural Science, New York, New York 10003.ORCID 0000-0003-4736-5528
Ana MirallaveCenter for Neural Science, New York, New York 10003.
Todd M MoweryCenter for Neural Science, New York, New York 10003.
Dan H SanesCenter for Neural Science, New York, New York 10003.
Center for Neuro-Oncology · USNYU Langone Health · US

Funding

Rescue of cortical inhibitory synapses following developmental hearing lossR01DC011284 · NIDCD · NEW YORK UNIVERSITY · PI SANES, DAN HARVEY · 2011 to 2022
$5.4M
NIDCD NIH HHS R01 DC011284
6 · The paper itself

Abstract

The perirhinal cortex (PRh) is a key region downstream of auditory cortex (ACx) that processes familiarity linked mnemonic signaling. In gerbils, ACx-driven EPSPs recorded in PRh neurons are largely shunted by GABAergic inhibition (Kotak et al., 2015, Frontiers in Neural Circuits, 9). To determine whether inhibitory shunting prevents the induction of excitatory long-term potentiation (e-LTP), we stimulated ACx-recipient PRh in a brain slice preparation using theta burst stimulation (TBS). Under control conditions, without GABA blockers, the majority of PRh neurons exhibited long-term depression. A very low concentration of bicuculline increased EPSP amplitude, but under this condition TBS did not significantly increase e-LTP induction. Since PRh synaptic inhibition included a GABA

Indexed as

AnimalsBicucullineElectric StimulationExcitatory Postsynaptic PotentialsGABA AntagonistsGerbillinaeLong-Term PotentiationMicroelectrodesNeural InhibitionNeuronsPerirhinal CortexReceptors, GABATissue Culture TechniquesBicucullineGABA AntagonistsReceptors, GABAauditory cortexGABAA receptorGABAB receptorLTPperirhinal cortex

Identifiers

PMID28881444
PMCPMC5745066
OpenAlexW2751941624

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.