Evidence map›Paper›PMID 28881383›Full record

ArticleCancer2017

Processes of code status transitions in hospitalized patients with advanced cancer.

Areej El-Jawahri, Kelsey Lau-Min, Ryan D Nipp, Joseph A Greer, Lara N Traeger, Samantha M Moran, Sara M D'Arpino, Ephraim P Hochberg, Vicki A Jackson, Barbara J Cashavelly and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Early and late code status documentation in cancer patients managed by a dedicated supportive care team.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  8. Associations of prognostic-awareness-transition patterns with end-of-life care in cancer patients' last month.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Areej El-JawahriDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.ORCID http://orcid.org/0000-0002-3556-1495
Kelsey Lau-MinDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Ryan D NippDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.ORCID http://orcid.org/0000-0002-4577-3248
Joseph A GreerDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Lara N TraegerHarvard Medical School, Boston, Massachusetts.
Samantha M MoranDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Sara M D'ArpinoDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Ephraim P HochbergDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Vicki A JacksonDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Barbara J CashavellyDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Holly S MartinsonDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
David P RyanDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Jennifer S TemelHarvard Medical School, Boston, Massachusetts.
Harvard University · USMassachusetts General Hospital · US

Funding

Dana Farber/Harvard Cancer Consortium Career Development Program in Clinical OncologyK12CA087723 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Tsai Ting · 2002 to 2026
$17.9M
Optimizing Palliative and End of Life Care for Patients with CancerK24CA181253 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI TEMEL, JENNIFER SUE · 2014 to 2018
$737k
NCI NIH HHS K12 CA087723NCI NIH HHS K24 CA181253NCI NIH HHS L30 CA209031
6 · The paper itself

Abstract

backgroundAlthough hospitalized patients with advanced cancer have a low chance of surviving cardiopulmonary resuscitation (CPR), the processes by which they change their code status from full code to do not resuscitate (DNR) are unknown.

methodsWe conducted a mixed-methods study on a prospective cohort of hospitalized patients with advanced cancer. Two physicians used a consensus-driven medical record review to characterize processes that led to code status order transitions from full code to DNR.

resultsIn total, 1047 hospitalizations were reviewed among 728 patients. Admitting clinicians did not address code status in 53% of hospitalizations, resulting in code status orders of "presumed full." In total, 275 patients (26.3%) transitioned from full code to DNR, and 48.7% (134 of 275 patients) of those had an order of "presumed full" at admission; however, upon further clarification, the patients expressed that they had wished to be DNR before the hospitalization. We identified 3 additional processes leading to order transition from full code to DNR acute clinical deterioration (15.3%), discontinuation of cancer-directed therapy (17.1%), and education about the potential harms/futility of CPR (15.3%). Compared with discontinuing therapy and education, transitions because of acute clinical deterioration were associated with less patient involvement (P = .002), a shorter time to death (P < .001), and a greater likelihood of inpatient death (P = .005).

conclusionsOne-half of code status order changes among hospitalized patients with advanced cancer were because of full code orders in patients who had a preference for DNR before hospitalization. Transitions due of acute clinical deterioration were associated with less patient engagement and a higher likelihood of inpatient death. Cancer 2017;123:4895-902. © 2017 American Cancer Society.

Indexed as

Resuscitation OrdersAgedAged, 80 and overCardiopulmonary ResuscitationCause of DeathCohort StudiesFemaleHospitalizationHospital MortalityHumansMaleMassachusettsMiddle AgedNeeds AssessmentNeoplasm InvasivenessNeoplasmsadvance care planningadvanced cancercardiopulmonary resuscitationcode statuscode status transitionsgoals of care

Identifiers

PMID28881383
PMCPMC5716901
OpenAlexW2753257903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.