Evidence map›Paper›PMID 28881355›Full record

Trial reportBritish journal of cancer2017

Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer.

Wendy Demark-Wahnefried, Soroush Rais-Bahrami, Renee A Desmond, Jennifer B Gordetsky, Gary R Hunter, Eddy S Yang, Maria Azrad, Andrew D Frugé, Yuko Tsuruta, Lyse A Norian and 2 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 6 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Effect of combined lifestyle intervention on cardiometabolic risk in cancer survivors: A systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Impact of exercise-based prehabilitation on cardiometabolic health in surgical patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
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  5. A systematic review examining socioeconomic factors in trials of interventions for men that report weight as an outcome.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Wendy Demark-WahnefriedDepartment of Nutrition Sciences, Wallace Tumor Institute, University of Alabama at Birmingham, 1824 6th Avenue South, Suite 102, Birmingham, AL 35294, USA.
Soroush Rais-BahramiUniversity of Alabama at Birmingham Comprehensive Cancer Center, Wallace Tumor Institute, 1824 6th Avenue South, Birmingham, AL 35294, USA.
Renee A DesmondUniversity of Alabama at Birmingham Comprehensive Cancer Center, Wallace Tumor Institute, 1824 6th Avenue South, Birmingham, AL 35294, USA.
Jennifer B GordetskyDepartment of Urology, University of Alabama at Birmingham, 619 19th Street South, Birmingham, AL 35233, USA.
Gary R HunterDepartment of Human Studies, University of Alabama at Birmingham, 901 13th Street South, Birmingham, AL 35294, USA.
Eddy S YangUniversity of Alabama at Birmingham Comprehensive Cancer Center, Wallace Tumor Institute, 1824 6th Avenue South, Birmingham, AL 35294, USA.
Maria AzradDepartment of Nutrition Sciences, Wallace Tumor Institute, University of Alabama at Birmingham, 1824 6th Avenue South, Suite 102, Birmingham, AL 35294, USA.
Andrew D FrugéDepartment of Nutrition Sciences, Wallace Tumor Institute, University of Alabama at Birmingham, 1824 6th Avenue South, Suite 102, Birmingham, AL 35294, USA.
Yuko TsurutaDepartment of Nutrition Sciences, Wallace Tumor Institute, University of Alabama at Birmingham, 1824 6th Avenue South, Suite 102, Birmingham, AL 35294, USA.
Lyse A NorianDepartment of Nutrition Sciences, Wallace Tumor Institute, University of Alabama at Birmingham, 1824 6th Avenue South, Suite 102, Birmingham, AL 35294, USA.
Roanne SegalDepartment of Medicine, University of Ottawa, 1053 Carling Avenue, Ottawa, ON K1Y 4E9, Canada.
William E GrizzleUniversity of Alabama at Birmingham Comprehensive Cancer Center, Wallace Tumor Institute, 1824 6th Avenue South, Birmingham, AL 35294, USA.
University of Alabama at Birmingham · USUniversity of Ottawa · CA

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James O Hill · 2000 to 2026
$31.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Collaborative Human Tissue NetworkUM1CA183728 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GRIZZLE, WILLIAM E. · 2014 to 2018
$3.7M
Exploring the Impact of Negative Energy Balance in Men with Prostate CancerR21CA161263 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEMARK-WAHNEFRIED, WENDY · 2012 to 2013
$341k
NCI NIH HHS P30 CA013148NCI NIH HHS R21 CA161263NCI NIH HHS UM1 CA183728NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

backgroundObesity is associated with aggressive prostate cancer. To explore whether weight loss favourably affects tumour biology and other outcomes, we undertook a presurgical trial among overweight and obese men with prostate cancer.

methodsThis single-blinded, two-arm randomised controlled trial explored outcomes of a presurgical weight loss intervention (WLI) that promoted ∼1 kg per week loss via caloric restriction and increased physical activity (PA). Forty overweight/obese men with clinically confirmed prostate cancer were randomised to the WLI presurgery or to a control arm; changes in weight, body composition, quality-of-life, circulating biomarkers, gene expression, and immunohistochemical markers in tumour and benign prostatic tissue were evaluated.

resultsThe study period averaged 50 days. Mean (s.d.) change scores for the WLI vs control arms were as follows: weight: -4.7 (3.1) kg vs -2.2 (4.4) kg (P=0.0508); caloric intake: -500 (636) vs -159 (600) kcal per day (P=0.0034); PA: +0.9 (3.1) vs +1.7 (4.6) MET-hours per day (NS); vitality: +5.3 (7.l4) vs -1.8 (8.1) (P=0.0491); testosterone: +55.1 (86.0) vs -48.3 (203.7) ng dl

conclusionsIntentional weight loss shows mixed effects on circulating biomarkers, tumour gene expression, and proliferative markers. More study is needed before recommending weight loss, in particular rapid weight loss, among men with prostate cancer.

Indexed as

Caloric RestrictionWeight LossAgedBiomarkersBiomarkers, TumorFollow-Up StudiesGene Expression ProfilingHumansMaleMiddle AgedNeoplasm GradingNeoplastic Cells, CirculatingObesityOverweightPrognosisProstatic NeoplasmsBiomarkersBiomarkers, Tumor

Identifiers

PMID28881355
PMCPMC5672928
OpenAlexW2753773656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.