Evidence map›Paper›PMID 28881331›Full record

ReviewCurrent opinion in genetics & development2017

Breaking down barriers: the evolution of cell invasion.

Taylor N Medwig, David Q Matus

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Imaging developmental cell cycles.Biophysical journal · 2021
    Review
  7. Article
  8. Actin dynamics during tumor cell dissemination.International review of cell and molecular biology · 2021
    Review
  9. A developmental gene regulatory network forDevelopment (Cambridge, England) · 2020
    Article
  10. Article
  11. ETS1 regulates Twist1 transcription in a KrasClinical & experimental metastasis · 2018
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Taylor N MedwigDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794-5215, USA.
David Q MatusDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794-5215, USA. Electronic address: david.matus@stonybrook.edu.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Elucidating the mechanisms underlying cell cycle regulation of invasive behaviorR01GM121597 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI MATUS, DAVID · 2017 to 2021
$2.1M
Elucidating the Gene Regulatory Networks that Specify Invasive BehaviorR00CA154870 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI MATUS, DAVID · 2014 to 2016
$737k
NCI NIH HHS R00 CA154870NIGMS NIH HHS R01 GM121597NIH HHS P40 OD010440
6 · The paper itself

Abstract

Cell invasion is a specialized cell behavior that likely co-evolved with the emergence of basement membranes in metazoans as a mechanism to break down the barriers that separate tissues. A variety of conserved and lineage-specific biological processes that occur during development and homeostasis rely on cell invasive behavior. Recent innovations in genome editing and live-cell imaging have shed some light on the programs that mediate acquisition of an invasive phenotype; however, comparative approaches among species are necessary to understand how this cell behavior evolved. Here, we discuss the contexts of cell invasion, highlighting both established and emerging model systems, and underscore gaps in our understanding of the evolution of this key cellular behavior.

Indexed as

Biological EvolutionAnimalsBasement MembraneCaenorhabditis elegansCell CommunicationGene Editing

Identifiers

PMID28881331
PMCPMC5716887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.