ReviewBlood transfusion = Trasfusione del sangue2017
Current misconceptions in diagnosis and management of iron deficiency.
Review in Blood transfusion = Trasfusione del sangue, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04083755 (Impact of Intravenous Iron Treatment of Preoperative Anemia in Patients With Lower Extremity Peripheral Artery Disease), which is not on this map. Cited by 71 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Intravenous Iron Treatment of Preoperative Anemia in Patients With Lower Extremity Peripheral Artery Disease
Who cites it
71 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review.World journal of gastroenterology · 2020Pooled it
- The use of platelet-rich plasma in oral surgery: a systematic review and meta-analysis.Blood transfusion = Trasfusione del sangue · 2019Pooled it
- Safety and efficacy of tranexamic acid for prevention of obstetric haemorrhage: an updated systematic review and meta-analysis.Blood transfusion = Trasfusione del sangue · 2018Pooled it
- Safety, pharmacokinetics, and pharmacodynamics of intravenous ferric carboxymaltose in children with iron deficiency anemia.Pediatric research · 2023Trial
- Benefits of pre-operative oral Sucrosomial® iron supplementation in cardiac surgery: influence of patient's baseline hemoglobin and gender.Blood transfusion = Trasfusione del sangue · 2023Trial
- On the relevance of preoperative haemoglobin optimisation within a Patient Blood Management programme for elective hip arthroplasty surgery.Blood transfusion = Trasfusione del sangue · 2020Trial
- Efficacy of topical tranexamic acid within a blood-saving programme for primary total hip arthroplasty: a pragmatic, open-label randomised study.Blood transfusion = Trasfusione del sangue · 2018Trial
- Screening for iron deficiency in young women: the predictive validity of a five-item screening instrument (IRON-5).Scandinavian journal of primary health care · 2026Article
- Management of iron deficiency anemia and the role of intravenous iron supplementation in patients undergoing cancer chemotherapy: a real-world retrospective study in Japan.International journal of clinical oncology · 2026Observational
- Article
- Effectiveness of Plan-Do-Check-Act Approach in Improving Patient Satisfaction and Quality of Care in Parenteral Iron Deficiency Treatment.Global journal on quality and safety in healthcare · 2026Article
- Association between non-anemic iron deficiency and outcomes following off-pump coronary artery bypass surgery: a retrospective analysis.Korean journal of anesthesiology · 2025Article
- Article
- Iron Deficiency Treatment in Heart Failure-Challenges and Therapeutic Solutions.Journal of clinical medicine · 2025Review
- Prehabilitation in Major Surgery: An Evaluation of Cost Savings in a Tertiary Hospital.Journal of clinical medicine · 2025Article
- Persistent impact of antenatal maternal anaemia on child brain structure at 6-7 years of age: a South African child health study.BMC medicine · 2025Article
- Iron Deficiency-More Than Just Anemia: A Literature Review.Journal of community hospital internal medicine perspectives · 2025Review
- Testing and treating anaemia in pregnant women in Bangladesh: a cross-sectional survey.BMJ public health · 2025Article
- Implementing first pillar of PBM in the Emergency Area: a missed opportunity?Blood transfusion = Trasfusione del sangue · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevention and treatment of iron deficiency is a major public health goal. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product which meets the needs of the patient. However, there are a number of non-evidence-based misconceptions regarding the diagnosis and management of iron deficiency, with or without anaemia, as well as inconsistency of terminology and lack of clear guidance on clinical pathways. In particular, the pathogenesis of iron deficiency is still frequently not addressed and iron not replaced, with indiscriminate red cell transfusion used as a default therapy. In our experience, this imprudent practice continues to be endorsed by non-evidence-based misconceptions. The intent of the authors is to provide a consensus that effectively challenges these misconceptions, and to highlight evidence-based alternatives for appropriate management (referred to as key points). We believe that this approach to the management of iron deficiency may be beneficial for both patients and healthcare systems. We stress that this paper solely presents the Authors' independent opinions. No pharmaceutical company funded or influenced the conception, development or writing of the manuscript.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.