ArticleJournal of toxicology and environmental health. Part A2017
The impact of repeated organophosphorus pesticide exposure on biomarkers and neurobehavioral outcomes among adolescent pesticide applicators.
Article in Journal of toxicology and environmental health. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Psychiatric Risk Implications From Behavioral and Neural Effects of Adolescent Exposure to Environmental Insecticides: A Systematic Review of Rodent Studies.Biological psychiatry · 2026Review
- Effects of Pesticide Exposure on Cognitive Functions in Agricultural Workers: A Systematic Review.Florence Nightingale journal of nursing · 2026Article
- Associations between concurrent neonicotinoid, pyrethroid, and organophosphate insecticide metabolites and neurocognitive performance in Ecuadorian adolescents.The Science of the total environment · 2025Article
- Effects of exposure to insecticides on sleep and neurobehavioural functioning in puberty and adolescence: a scoping review.Arhiv za higijenu rada i toksikologiju · 2025Article
- Early-Life Exposure to Commercial Formulation Containing Deltamethrin and Cypermethrin Insecticides Impacts Redox System and Induces Unexpected Regional Effects in Rat Offspring Brain.Antioxidants (Basel, Switzerland) · 2023Article
- Review
- Determination of genotoxic damages of picloram and dicamba with comet assay in Allium cepa rooted in tissue culture and distilled water.Molecular biology reports · 2022Article
- Association between pesticide exposure and neurobehavioral performance of agricultural workers: A cross-sectional study.Brain and behavior · 2022Article
- Impact of Micronutrient Supplementation on Pesticide Residual, Acetylcholinesterase Activity, and Oxidative Stress Among Farm Children Exposed to Pesticides.Frontiers in public health · 2022Article
- Reliability of a computer-based neurobehavioral assessment test battery for Bangladeshi adolescent children.Neurotoxicology · 2021Article
- Article
- Evaluation of occupational pesticide exposure on Egyptian male adolescent cognitive and motor functioning.Environmental research · 2021Article
- Associations of the Behavioral Assessment and Research System (BARS) neurobehavioral outcomes with attention problems in children living near coal ash storage sites.Neurotoxicology · 2020Article
- Magnetic solid phase extraction sorbents using methyl-parathion and quinalphos dual-template imprinted polymers coupled with GC-MS for class-selective extraction of twelve organophosphorus pesticides.Mikrochimica acta · 2020Article
- Concentrations and temporal trends in pesticide biomarkers in urine of Swedish adolescents, 2000-2017.Journal of exposure science & environmental epidemiology · 2020Article
- Monitoring of the Organophosphate Pesticide Chlorpyrifos in Vegetable Samples from Local Markets in Northern Thailand by Developed Immunoassay.International journal of environmental research and public health · 2020Article
- Risk perception and behavior in Egyptian adolescent pesticide applicators: an intervention study.BMC public health · 2020Article
- Magnitude of behavioral deficits varies with job-related chlorpyrifos exposure levels among Egyptian pesticide workers.Neurotoxicology · 2020Article
- Residential proximity to greenhouse agriculture and neurobehavioral performance in Ecuadorian children.International journal of hygiene and environmental health · 2020Article
- Occupational pesticide exposure and symptoms of attention deficit hyperactivity disorder in adolescent pesticide applicators in Egypt.Neurotoxicology · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Egyptian adolescents are hired as seasonal workers to apply pesticides to the cotton crop and may perform this occupation for several years. However, few studies examined the effects of repeated pesticide exposure on health outcomes The goal of this study was to determine the impact of repeated pesticide exposure on neurobehavioral (NB) performance and biomarkers of exposure (urinary metabolite) and effect (cholinesterase activity). Eighty-four adolescents from two field stations in Menoufia, Egypt, were examined four times: before and during pesticide application season in 2010 and again before and during application season in 2011. At each of the four time points, participants completed a questionnaire, performed an NB test battery, and were assessed for urinary levels of the chlorpyrifos metabolite TCPy (3,5,6-trichloro-2-pyridinol) and blood cholinesterase activity. Following the study cohort over two consecutive pesticide application seasons revealed that TCPy levels significantly increased following exposure, and returned to baseline levels following the end of the application season. Blood butyryl cholinesterase activity exhibited a similar pattern. Although NB outcomes displayed learning and practice effects over time, deficits in performance were significantly associated with increased TCPy levels with reduction in the number of NB measures showing improvement over time. Biomarkers of exposure and effect demonstrated changes associated with pesticide application and recovery after application ended. Deficits in NB performance were correlated with elevated pesticide exposure. Data demonstrated that repeated pesticide exposure may exert a long-term adverse impact on human health.
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