Evidence map›Paper›PMID 28880430›Full record

ReviewTherapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy2017

Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner.

Sarah Abbes, Ara Metjian, Alice Gray, Tereza Martinu, Laurie Snyder, Dong-Feng Chen, Matthew Ellis, Gowthami M Arepally, Oluwatoyosi Onwuemene

Open access · bronzeAbstract readReview
In one paragraph

Review in Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Preventing Rejection of the Kidney Transplant.Journal of clinical medicine · 2023
    Review
  4. Article
  5. Article
  6. Immunology and Donor-Specific Antibodies in Corneal Transplantation.Archivum immunologiae et therapiae experimentalis · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 3 countries.

Sarah AbbesInstitut du thorax, Service de pneumologie et unite de transplantation thoracique, Centre Hospitalier Universitaire, Nantes, France.
Ara MetjianDepartment of Medicine, Division of Hematology, Duke University School of Medicine, Durham, NC, USA.
Alice GrayDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, NC, USA.
Tereza MartinuDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, NC, USA.
Laurie SnyderDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, NC, USA.
Dong-Feng ChenDepartment of Pathology, Division of Pathology Clinical Services, Duke University School of Medicine, Durham, NC, USA.
Matthew EllisDepartment of Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC, USA.
Gowthami M ArepallyDepartment of Medicine, Division of Hematology, Duke University School of Medicine, Durham, NC, USA.
Oluwatoyosi OnwuemeneDepartment of Medicine, Division of Hematology, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0001-7266-7101
Duke University · US

Funding

Duke-UNC Clinical Hematology Research Career Development ProgramK12HL087097 · NHLBI · DUKE UNIVERSITY · PI TELEN, MARILYN J · 2006 to 2016
$4.0M
NHLBI NIH HHS K12 HL087097NHLBI NIH HHS L30 HL129439
6 · The paper itself

Abstract

The human leukocyte antigen (HLA) system is an important immunologic barrier that must be considered for successful solid organ transplantation. Formation of donor-specific HLA antibodies in solid organ transplantation is an important cause of allograft injury and may contribute to recipient morbidity and mortality. Therapeutic plasma exchange is often requested to lower HLA antibody levels prior to or after transplantation and for management of HLA antibodies in the context of organ rejection. In this review, we summarize the current terminology, laboratory testing, and clinical significance of HLA sensitization in the solid organ transplant population. Furthermore, to illustrate applications of HLA testing in clinical practice, we summarize our own lung and kidney institutional protocols for managing HLA antibodies in the peri-transplant setting.

Indexed as

Blood Component RemovalGraft RejectionHLA AntigensHumansKidney TransplantationLung TransplantationOrgan TransplantationPlasma ExchangeTerminology as TopicTissue DonorsHLA AntigensHuman leukocyte antigen antibodiesHuman leukocyte antigen sensitizationSolid organ transplantationTherapeutic plasma exchange

Identifiers

PMID28880430
PMCPMC6890204
OpenAlexW2753325343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.