ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2017
Catheter Hydrophone Aberration Correction for Transcranial Histotripsy Treatment of Intracerebral Hemorrhage: Proof-of-Concept.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2021Pooled it
- Early adoption of image-guided histotripsy therapy in interventional oncology: challenges and opportunities in the United Kingdom.The British journal of radiology · 2026Review
- Review
- MR-Cavitation Dynamics Encoded (MR-CaDE) imaging.Magnetic resonance in medicine · 2025Article
- Ultrasound imaging guided precision histotripsy: Effects of pulse settings on ablation properties in rat brain.The Journal of the Acoustical Society of America · 2024Article
- Transcranial Histotripsy Clot and Tissue Ablation for Intracerebral Hemorrhage Evacuation and Other Brain Applications.Stroke (Hoboken, N.J.) · 2024Article
- Histotripsy Treatment of Murine Brain and Glioma: Temporal Profile of Magnetic Resonance Imaging and Histological Characteristics Post-treatment.Ultrasound in medicine & biology · 2023Article
- Research progress and clinical evaluation of histotripsy: a narrative review.Annals of translational medicine · 2023Review
- A Modular, Kerf-Minimizing Approach for Therapeutic Ultrasound Phased Array Construction.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Two-step aberration correction: application to transcranial histotripsy.Physics in medicine and biology · 2022Article
- Transcostal Histotripsy Ablation in an In Vivo Acute Hepatic Porcine Model.Cardiovascular and interventional radiology · 2021Article
- Bubble Cloud Behavior and Ablation Capacity for Histotripsy Generated from Intrinsic or Artificial Cavitation Nuclei.Ultrasound in medicine & biology · 2021Article
- Stereotactic Transcranial Focused Ultrasound Targeting System for Murine Brain Models.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Histotripsy: Potential Noninvasive Management of Intracerebral Hemorrhage.World neurosurgery · 2020Article
- Real-Time Transcranial Histotripsy Treatment Localization and Mapping Using Acoustic Cavitation Emission Feedback.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Histotripsy Clot Liquefaction in a Porcine Intracerebral Hemorrhage Model.Neurosurgery · 2020Article
- Soft-Tissue Aberration Correction for Histotripsy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2018Article
- The influence of medium elasticity on the prediction of histotripsy-induced bubble expansion and erythrocyte viability.Physics in medicine and biology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Histotripsy is a minimally invasive ultrasound therapy that has shown rapid liquefaction of blood clots through human skullcaps in an in vitro intracerebral hemorrhage model. However, the efficiency of these treatments can be compromised if the skull-induced aberrations are uncorrected. We have developed a catheter hydrophone which can perform aberration correction (AC) and drain the liquefied clot following histotripsy treatment. Histotripsy pulses were delivered through an excised human skullcap using a 256-element, 500-kHz hemisphere array transducer with a 15-cm focal distance. A custom hydrophone was fabricated using a mm PZT-5h crystal interfaced to a coaxial cable and integrated into a drainage catheter. An AC algorithm was developed to correct the aberrations introduced between histotripsy pulses from each array element. An increase in focal pressure of up to 60% was achieved at the geometric focus and 27%-62% across a range of electronic steering locations. The sagittal and axial -6-dB beam widths decreased from 4.6 to 2.2 mm in the sagittal direction and 8 to 4.4 mm in the axial direction, compared to 1.5 and 3 mm in the absence of aberration. After performing AC, lesions with diameters ranging from 0.24 to 1.35 mm were generated using electronic steering over a mm grid in a tissue-mimicking phantom. An average volume of 4.07 ± 0.91 mL was liquefied and drained after using electronic steering to treat a 4.2-mL spherical volume in in vitro bovine clots through the skullcap.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.