Evidence map›Paper›PMID 28879579›Full record

ArticleJournal of the American Society for Mass Spectrometry2017

Novel Selectivity-Based Forensic Toxicological Validation of a Paper Spray Mass Spectrometry Method for the Quantitative Determination of Eight Amphetamines in Whole Blood.

Sebastiaan F Teunissen, Patrick W Fedick, Bjorn J A Berendsen, Michel W F Nielen, Marcos N Eberlin, R Graham Cooks, Arian C van Asten

Open access · greenAbstract readValidation Study
PubMed Publisher
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Sebastiaan F TeunissenThoMSon Mass Spectrometry Laboratory, University of Campinas - UNICAMP, Campinas, 13083-970, Brazil.
Patrick W FedickDepartment of Chemistry and Center for Analytical Instrumentation, Purdue University, West Lafayette, IN, 47907, USA.
Bjorn J A BerendsenRIKILT, Wageningen Research, Akkermaalsbos 2, 6708 WB, P.O. Box 230, 6700 AE, Wageningen, The Netherlands.
Michel W F NielenRIKILT, Wageningen Research, Akkermaalsbos 2, 6708 WB, P.O. Box 230, 6700 AE, Wageningen, The Netherlands.
Marcos N EberlinThoMSon Mass Spectrometry Laboratory, University of Campinas - UNICAMP, Campinas, 13083-970, Brazil.
R Graham CooksDepartment of Chemistry and Center for Analytical Instrumentation, Purdue University, West Lafayette, IN, 47907, USA.
Arian C van AstenNetherlands Forensic Institute, P.O. Box 24044, 2490 AA, The Hague, The Netherlands. a.van.asten@nfi.minvenj.nl.
Purdue University West Lafayette · USWageningen University & Research · NLNetherlands Forensic Institute · NLUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paper spray tandem mass spectrometry is used to identify and quantify eight individual amphetamines in whole blood in 1.3 min. The method has been optimized and fully validated according to forensic toxicology guidelines, for the quantification of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-N-methylamphetamine (MDMA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA), para-methoxyamphetamine (PMA), para-methoxymethamphetamine (PMMA), and 4-fluoroamphetamine (4-FA). Additionally, a new concept of intrinsic and application-based selectivity is discussed, featuring increased confidence in the power to discriminate the amphetamines from other chemically similar compounds when applying an ambient mass spectrometric method without chromatographic separation. Accuracy was within ±15% and average precision was better than 15%, and better than 20% at the LLOQ. Detection limits between 15 and 50 ng/mL were obtained using only 12 μL of whole blood. Graphical abstract ᅟ.

Indexed as

AmphetamineCentral Nervous System StimulantsForensic ToxicologyHumansLimit of DetectionMass SpectrometryPaperReproducibility of ResultsSubstance Abuse DetectionAmphetamineCentral Nervous System StimulantsAmphetaminesForensic toxicologyPaper spray mass spectrometrySelectivityValidationWhole blood

Identifiers

PMID28879579
OpenAlexW2752723180

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.