ArticleBrain structure & function2018
Brain cortical characteristics of lifetime cognitive ageing.
Article in Brain structure & function, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
- Culture, prefrontal volume, and memory.PloS one · 2024Trial
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- Prenatal alcohol exposure alters brain structure and neurocognitive outcomes for 6- to 7-year-old children in a South African birth cohort.Alcohol, clinical & experimental research · 2025Article
- rsfMRI-based brain entropy is negatively correlated with gray matter volume and surface area.Brain structure & function · 2025Article
- Obesity accelerates brain ageing: a multimodal imaging study.Brain communications · 2025Article
- Detection of Alzheimer's Disease Using Hybrid Meta-ROI of MRI Structural Images.Diagnostics (Basel, Switzerland) · 2024Article
- Significant Acceleration of Regional Brain Aging and Atrophy After Mild Traumatic Brain Injury.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Longitudinal change-change associations of cognition with cortical thickness and surface area.Aging brain · 2023Article
- White matter and gray matter changes related to cognition in community populations.Frontiers in aging neuroscience · 2023Article
- Causal effects of cingulate morphology on executive functions in healthy young adults.Human brain mapping · 2022Article
- Inter- and intra-individual variation in brain structural-cognition relationships in aging.NeuroImage · 2022Article
- Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Mapping brain structural differences and neuroreceptor correlates in Parkinson's disease visual hallucinations.Nature communications · 2022Article
- Musicianship-Related Structural and Functional Cortical Features Are Preserved in Elderly Musicians.Frontiers in aging neuroscience · 2022Article
- Neuroanatomical norms in the UK Biobank: The impact of allometric scaling, sex, and age.Human brain mapping · 2021Article
- A history of previous childbirths is linked to women's white matter brain age in midlife and older age.Human brain mapping · 2021Article
- Magnetic Resonance Imaging Measurement of Entorhinal Cortex in the Diagnosis and Differential Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease.Brain sciences · 2021Article
- Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling.Journal of neuroengineering and rehabilitation · 2021Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
Regional cortical brain volume is the product of surface area and thickness. These measures exhibit partially distinct trajectories of change across the brain's cortex in older age, but it is unclear which cortical characteristics at which loci are sensitive to cognitive ageing differences. We examine associations between change in intelligence from age 11 to 73 years and regional cortical volume, surface area, and thickness measured at age 73 years in 568 community-dwelling older adults, all born in 1936. A relative positive change in intelligence from 11 to 73 was associated with larger volume and surface area in selective frontal, temporal, parietal, and occipital regions (r < 0.180, FDR-corrected q < 0.05). There were no significant associations between cognitive ageing and a thinner cortex for any region. Interestingly, thickness and surface area were phenotypically independent across bilateral lateral temporal loci, whose surface area was significantly related to change in intelligence. These findings suggest that associations between regional cortical volume and cognitive ageing differences are predominantly driven by surface area rather than thickness among healthy older adults. Regional brain surface area has been relatively underexplored, and is a potentially informative biomarker for identifying determinants of cognitive ageing differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.