ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
Pregnancy-related fractures: a retrospective study of a French cohort of 52 patients and review of the literature.
Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Pregnancy and Lactation Associated Osteoporosis: A Systematic Review.Calcified tissue international · 2026Pooled it
- Clinical presentation, risk factors and management of pregnancy-associated osteoporosis: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- Comparative Effectiveness of Therapeutic Interventions in Pregnancy and Lactation-Associated Osteoporosis: A Systematic Review and Meta-analysis.The Journal of clinical endocrinology and metabolism · 2024Pooled it
- Pregnancy- and lactation-associated osteoporosis with vertebral fractures: a systematic review.BMC musculoskeletal disorders · 2021Pooled it
- Postpartum timing of teriparatide initiation and BMD response in pregnancy- and lactation-associated osteoporosis: an observational study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Observational
- Effects of pregnancy and lactation-associated osteoporosis on children: analysis using linked mother and child data.Journal of bone and mineral metabolism · 2026Article
- Genetic contributors to osteoporosis in pregnancy and lactation associated osteoporosis (PLO).Bone · 2026Article
- Real-world treatment outcomes in pregnancy and lactation-associated osteoporosis: a nationwide multicenter cohort study.Frontiers in endocrinology · 2026Observational
- Effective management of pregnancy- and lactation-associated osteoporosis using romosozumab: a clinical case report.JBMR plus · 2025Article
- Pregnancy and Lactation Associated Bone Fragility.Journal of the Endocrine Society · 2025Review
- Gene Variants and Bisphosphonates Treatment in Pregnancy and Lactation-Associated Osteoporosis (PLO): A Retrospective Study of 22 Chinese Patients.Calcified tissue international · 2025Article
- [Pregnancy and lactation-associated osteoporosis: risk factors and treatment].Zeitschrift fur Rheumatologie · 2025Article
- Disorders of bone and mineral metabolism in pregnancy and lactation: A case based clinical review.Osteoporosis and sarcopenia · 2025Review
- Identifying risk factors for pregnancy and lactation-associated osteoporosis: insights from an Italian survey in PLAO patients and controls.Frontiers in endocrinology · 2025Article
- HR-pQCT reveals marked trabecular and cortical structural deficits in women with pregnancy and lactation-associated osteoporosis (PLO).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Pregnancy and Lactation Associated Osteoporosis in a 24-Year-Old Presenting with Multiple Fragility Fractures in the Dorsolumbar Spine: A Case Report and Review of Literature.Journal of orthopaedic case reports · 2024Article
- Effective strategies for pregnancy and lactation-associated osteoporosis: teriparatide use in focus.Endocrine · 2024Review
- Pregnancy- and Lactation-Associated Osteoporosis: A Literature Review Based on a Clinical Case.Cureus · 2024Article
- Pregnancy and lactation associated osteoporotic vertebral fracture: the neurosurgical perspective through a multicentric study.Neurosurgical review · 2024Article
- Multiple Vertebral Compression Fractures Secondary to Pregnancy-induced Osteoporosis: A Case Report.Journal of orthopaedic case reports · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A retrospective, multicentre study involving 52 patients was carried out to define the causes and characteristics of pregnancy-related osteoporosis. The mean number of vertebral fractures occurring during the last trimester of pregnancy or at the time of delivery was 3.8. This is often promoted by risk factors before or during pregnancy.
introductionIn order to define the causes or predisposing factors of pregnancy-related osteoporosis and its clinical, radiological and bone density characteristics, laboratory findings, course and outcome, we carried out a retrospective multicentre study.
methodsThe records of 52 women hospitalised over the last 10 years in the rheumatology departments of six French university hospitals and with a diagnosis of pregnancy-related osteoporosis were examined.
resultsThe patients' mean age at time of fracture was 32.1 years. In 10 patients, the fractures had occurred during the last trimester of pregnancy, and in 36 at the time of delivery or during the first 2 months post-partum. The mean number of vertebral fractures was 3.8 ± 2.0. Thirty three of the 52 patients had a risk factor of low bone mass before pregnancy. Twelve had disorders or treatments (heparin) that might promote osteoporosis during pregnancy, while 14 had no trigger factors before or during pregnancy. Overall, phosphate and calcium levels were normal, except for hyperphosphoraemia in lactating women (90%). On DXA scan, osteoporosis predominated in the trabecular bone (spinal T-score - 3.4, hip T-score - 2). Only 10 patients had a repeat fracture, and the increase in bone mineral density during follow-up was considerable, and improved by bisphosphonates (annual gain + 10% in the spine) or teriparatide (+ 15%).
conclusionsPregnancy-related osteoporosis gives rise to multiple vertebral fractures. It is often promoted by risk factors before or during pregnancy. Its mechanism is still unknown. Treatment with bisphosphonates or teriparatide appears to improve the recovery of bone mineral density.
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