ArticleJournal of neurology2017
Parkinsonian symptoms in normal pressure hydrocephalus: a population-based study.
Article in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06857136 (The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Clinical predictors of shunt response in the diagnosis and treatment of idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis.Acta neurochirurgica · 2021Pooled it
- Clinical and Radiological Evolution of Idiopathic Normal Pressure Hydrocephalus: A Critical Review.Movement disorders clinical practice · 2026Review
- Article
- Technological Advances for Gait and Balance in Normal Pressure Hydrocephalus: A Systematic Review.Bioengineering (Basel, Switzerland) · 2025Review
- Automated Idiopathic Normal Pressure Hydrocephalus Diagnosis via Artificial Intelligence-Based 3D T1 MRI Volumetric Analysis.AJNR. American journal of neuroradiology · 2025Article
- Evaluation of disproportionately enlarged subarachnoid-space hydrocephalus in progressive supranuclear palsy.Brain communications · 2025Article
- Experience from a Fast-Track Multidisciplinary Clinic Integrating Movement Disorders Neurologists in Normal Pressure Hydrocephalus Evaluation.Journal of clinical medicine · 2024Article
- Levodopa-resistant parkinsonism developing after ventriculoperitoneal shunting for obstructive hydrocephalus and improving after endoscopic third ventriculostomy, with specific consideration of brainstem morphology: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus Patient With Parkinson's Disease-Compatible Findings on Dopamine Transporter Scans.Dementia and neurocognitive disorders · 2024Article
- Freezing of gait in idiopathic normal pressure hydrocephalus.Fluids and barriers of the CNS · 2024Article
- Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography.AJNR. American journal of neuroradiology · 2024Article
- Awareness level of idiopathic normal pressure hydrocephalus among health-care providers.Surgical neurology international · 2024Article
- Structural neuroimaging markers of normal pressure hydrocephalus versus Alzheimer's dementia and Parkinson's disease, and hydrocephalus versus atrophy in chronic TBI-a narrative review.Frontiers in neurology · 2024Review
- Risk estimation for idiopathic normal-pressure hydrocephalus: development and validation of a brain morphometry-based nomogram.European radiology · 2023Article
- Idiopathic Normal Pressure Hydrocephalus and Progressive Supranuclear Palsy: Two Single Entities or Neurodegenerative Overlap Syndrome? A Case Report.Medicina (Kaunas, Lithuania) · 2023Article
- Turning and Sitting in Early Parkinsonism: Differences Between Idiopathic Normal Pressure Hydrocephalus Associated with Parkinsonism and Parkinson's Disease.Movement disorders clinical practice · 2023Article
- Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population-based study.BMC geriatrics · 2023Article
- In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome.Fluids and barriers of the CNS · 2022Article
- Alzheimer's Disease CSF Biomarker Profiles in Idiopathic Normal Pressure Hydrocephalus.Journal of personalized medicine · 2022Article
- Clinical Aspects of the Differential Diagnosis of Parkinson's Disease and Parkinsonism.Journal of clinical neurology (Seoul, Korea) · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It may be challenging to differentiate normal pressure hydrocephalus (NPH) from neurodegenerative disorders such as Parkinson's disease. In this population-based study, we wanted to describe the frequency of parkinsonian symptoms among individuals with and without NPH, and whether the motor examination part of the Unified Parkinson's Disease Rating Scale (UPDRS-m) score differs between these groups. Furthermore, we wanted to find out whether there was a relationship between UPDRS-m score, NPH symptoms, and radiological signs of NPH. A sample of 168 individuals over the age of 65 with and without self-reported symptoms of NPH underwent a computerized tomography of the brain and clinical examination, including UPDRS-m to grade parkinsonian symptoms. According to diagnostic guidelines, 38 fulfilled criteria for NPH, whereas 130 had unlikely NPH. Bradykinesia was significantly more common among those with NPH (79%) compared to those with unlikely NPH (32%) (p < 0.001). The corresponding figures for rigidity were 43 vs. 15% (p < 0.001), for postural instability 71 vs. 22% (p < 0.001), and for tremor at rest 5 vs. 6% (not significant). The total UPDRS-m score was significantly higher among individuals with NPH (median = 12) than without (median = 1) and correlated significantly with the degree of NPH symptoms (r = -0.72) and ventriculomegaly (r = 0.31). In this study, parkinsonian symptoms, except resting tremor, were frequent in individuals with NPH and correlated with the severity of NPH symptoms. Asymmetric symptoms were uncommon. We recommend a liberal use of neuroradiological imaging when investigating a patient with parkinsonian features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.