ArticleJournal of neurology2017
Do cognition and other non-motor symptoms decline similarly among patients with Parkinson's disease motor subtypes? Findings from a 5-year prospective study.
Article in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of transcranial direct current stimulation on non-motor functions in individuals with Parkinson's disease: a systematic review and meta-analysis.Frontiers in neuroscience · 2025Pooled it
- Transcranial direct current stimulation combined with physical or cognitive training in people with Parkinson's disease: a systematic review.Journal of neuroengineering and rehabilitation · 2020Pooled it
- Dual-tracer [Quantitative imaging in medicine and surgery · 2026Article
- Association of the DTI-ALPS index with motor and non-motor symptoms in Parkinson's disease with postural instability/gait difficulty: a diffusion tensor MRI study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Digital and traditional recruitment strategies and participation patterns in the multicenter Healthy Brain Ageing study.Frontiers in digital health · 2026Article
- The comparison of gait disorders among different motor subtypes in Parkinson's disease patients during the early and middle stages.Clinical parkinsonism & related disorders · 2025Article
- Rehabilitation Response in Tremor- and Non-Tremor-Dominant Parkinson Disease: A Task-fMRI Study.Brain and behavior · 2024Article
- Neuroimaging correlates of postural instability in Parkinson's disease.Journal of neurology · 2024Article
- Altered connectivity between frontal cortex and supplementary motor area in various types of Parkinson's disease.American journal of translational research · 2024Article
- Carpets with visual cues can improve gait in Parkinson's disease patients: may be independent of executive function.European journal of medical research · 2023Article
- Speech and gait abnormalities in motor subtypes of de-novo Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- Unlocking potential: low frequency subthalamic nucleus stimulation enhances executive function in Parkinson's disease patients with postural instability/gait disturbance.Frontiers in neuroscience · 2023Article
- Free water imaging unravels unique patterns of longitudinal structural brain changes in Parkinson's disease subtypes.Frontiers in neurology · 2023Article
- APOE E4 is associated with impaired self-declared cognition but not disease risk or age of onset in Nigerians with Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Cortical Serotonergic and Catecholaminergic Denervation in MPTP-Treated Parkinsonian Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The emerging postural instability phenotype in idiopathic Parkinson disease.NPJ Parkinson's disease · 2022Article
- Bilateral globus pallidus interna deep brain stimulation in Parkinson's disease: Therapeutic effects and motor outcomes prediction in a short-term follow up.Frontiers in human neuroscience · 2022Article
- Pedunculopontine Nucleus Dysconnectivity Correlates With Gait Impairment in Parkinson's Disease: An Exploratory Study.Frontiers in aging neuroscience · 2022Article
- The Impact of Sex on the Neurocognitive Functions of Patients with Parkinson's Disease.Brain sciences · 2021Article
- Progression in Parkinson's Disease: Variation in Motor and Non-motor Symptoms Severity and Predictors of Decline in Cognition, Motor Function, Disability, and Health-Related Quality of Life as Assessed by Two Different Methods.Movement disorders clinical practice · 2021Article
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5 authors.
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Abstract
Among patients with Parkinson's disease (PD), a wide range of motor and non-motor symptoms (NMS) are evident. PD is often divided into tremor dominant (TD) and postural instability gait difficulty (PIGD) motor subtypes. We evaluated the effect of disease duration and aimed to characterize whether there are differences in the deterioration of cognitive function and other NMS between the PIGD and TD subtypes. Sixty-three subjects were re-evaluated at the follow-up visit about 5 years after baseline examination. Cognitive function and other NMS were assessed. At follow-up, the PIGD and TD groups were similar with respect to medications, comorbidities and disease-related symptoms. There was a significant time effect for all measures, indicating deterioration and worsening in both groups. However, cognitive scores, particularly those related to executive function, became significantly worse in the PIGD with a more moderate decrease in the TD group. For example, the computerized global cognitive score declined in the PIGD group from 94.21 ± 11.88 to 83.91 ± 13.76, p < 0.001. This decline was significantly larger (p = 0.03) than the decrease observed in the TD group (96.56 ± 10.29 to 92.21 ± 14.20, p = 0.047). A significant group × time interaction effect was found for the change in global cognitive score (p = 0.047), the executive function index (p = 0.002) and accuracy on a motor-cognitive catch game (p = 0.008). In contrast, several NMS including depression, health-related quality of life and fear of falling deteriorated in parallel in both subtypes, with no interaction effect. The present findings highlight the difference in the natural history of the disease between the two PD "motor" subtypes. While the PIGD group demonstrated a significant cognitive decline, especially in executive functions, a more favorable course was observed in the TD subtype. This behavior was not seen in regards to the other NMS.
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