ArticleJournal of dental anesthesia and pain medicine2017
Propofol protects against oxidative-stress-induced COS-7 cell apoptosis by inducing autophagy.
Article in Journal of dental anesthesia and pain medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC.Cell communication and signaling : CCS · 2023Article
- Propofol Induces the Expression of Nrf2 and HO-1 inTropical medicine and infectious disease · 2023Article
- Propofol protects against oxygen/glucose deprivation‑induced cell injury via gap junction inhibition in astrocytes.Molecular medicine reports · 2020Article
- Article
- The protective effect of propofol on ionizing radiation-induced hematopoietic system damage in mice.RSC advances · 2019Article
- Ischaemic and hypoxic conditioning: potential for protection of vital organs.Experimental physiology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn oxidative stress, reactive oxygen species (ROS) production contributes to cellular dysfunction and initiates the apoptotic cascade. Autophagy is considered the mechanism that decreases ROS concentration and oxidative damage. Propofol shows antioxidant properties, but the mechanisms underlying the effect of propofol preconditioning (PPC) on oxidative injury remain unclear. Therefore, we investigated whether PPC protects against cell damage from hydrogen peroxide (H
methodCOS-7 cells were randomly divided into the following groups: control, cells were incubated in normoxia (5% CO
resultsCell viability decreased more significantly in the H
conclusionPPC has a protective effect on H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.