ArticleJournal of dental anesthesia and pain medicine2017
4% lidocaine versus 4% articaine for inferior alveolar nerve block in impacted lower third molar surgery.
Article in Journal of dental anesthesia and pain medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Efficacy comparison of articaine versus lidocaine in dental anesthesia: a meta-analysis of randomized controlled trials.BMC anesthesiology · 2026Pooled it
- Evaluation of different mandibular blocks for the removal of lower third molars: a meta-analysis of randomised clinical trials.Clinical oral investigations · 2021Pooled it
- Effectiveness of anesthetic solutions for pain control in lower third molar extraction surgeries: a systematic review of randomized clinical trials with network meta-analysis.Clinical oral investigations · 2021Pooled it
- Local anaesthesia for surgical extraction of mandibular third molars: a systematic review and network meta-analysis.Clinical oral investigations · 2020Pooled it
- Clinical Outcomes of Low-Dose Intranasal Midazolam for Severe Gag Reflex in Endodontic Patients: A Retrospective Case Series Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
- Evaluating Pain Response and Clinical Efficacy of an Articaine Mucoadhesive Patch among 6-12-year-old Children during Local Anesthetic Injection and Subgingival Tooth Preparation: A Double-blind Nonrandomized Clinical Trial.International journal of clinical pediatric dentistry · 2025Article
- Anesthetic effect of articaine and lidocaine in tooth extraction.Bioinformation · 2025Article
- A Comparative Evaluation of Pain Experience and Time of Onset of 2% Lignocaine and 4% Articaine in Inferior Alveolar Nerve Block among Pediatric Population: A Clinical Study.International journal of clinical pediatric dentistry · 2024Article
- Why choose articaine over lidocaine for the removal of third molars? Systematic review and meta-analysis.Journal of clinical and experimental dentistry · 2023Review
- Review
- Article
- Use of Phentolamine Mesylate in Implant Surgery: Analysis of Adverse Effects and Haemodynamic Changes.Journal of clinical medicine · 2021Article
- Accidental Intravascular Local Anesthetic Injection of the Facial Artery.Anesthesia progress · 2021Article
- Dexamethasone Injection Into Pterygomandibular Space Versus Sublingual Space on Post-Operative Sequalae of Lower Third Molar Intervention.Journal of clinical medicine research · 2019Article
- Efficacy of dental local anesthetics: A review.Journal of dental anesthesia and pain medicine · 2018Review
- Local anesthesia for mandibular third molar extraction.Journal of dental anesthesia and pain medicine · 2018Review
- Comparative evaluation of the efficacy, safety, and hemostatic effect of 2% lidocaine with various concentrations of epinephrine.Journal of dental anesthesia and pain medicine · 2018Article
- Double versus single cartridge of 4% articaine infiltration into the retro-molar area for lower third molar surgery.Journal of dental anesthesia and pain medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo study has compared lidocaine with articaine, each at a concentration of 4% and combined with epinephrine. The purpose of this study was to compare the effectiveness of 4% lidocaine with that of 4% articaine, with a concentration of 1:100,000 epinephrine added to each, in an inferior alveolar nerve block for surgery on impacted lower third molars.
methodThis study was conducted at the Faculty of Dentistry, Mahidol University in Bangkok, Thailand. The randomized, single-blind, comparative split-mouth study was carried out in patients with symmetrically impacted lower third molars, as identified on panoramic radiographs. Each patient underwent surgery for the removal of the lower third molars by the same surgeon under local anesthesia at two separate visits, 3 weeks apart. The onset and duration of local anesthesia, intra-operative pain, surgical duration, and number of additional anesthetics administered were recorded.
resultsThe subjective and objective onset of action for the local anesthetics showed statistically significant differences (P < 0.05). However, the intra-operative pain, surgical duration, duration of local anesthesia, and number of additional anesthetics administered did not show statistically significant differences.
conclusionThe use of 4% articaine for the inferior alveolar nerve block was clinically more effective in the onset of subjective and objective anesthesia as compared with the use of 4% lidocaine. Based on the pain scores from the visual analogue scale, 4% lidocaine provided more analgesia during the procedure, and patients noted less intra-operative pain than with 4% articaine; however, the difference was not clinically significant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.