ArticleJournal of dental anesthesia and pain medicine2016
The efficacy of dexamethasone injection on postoperative pain in lower third molar surgery.
Article in Journal of dental anesthesia and pain medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Can adjunctive corticosteroid therapy improve patient-centered outcomes following third molar surgery? A systematic review.Medicina oral, patologia oral y cirugia bucal · 2022Pooled it
- Intramasseteric versus pterygomandibular space dexamethasone injection for oedema and trismus after mandibular third molar surgery: a randomised split-mouth clinical trial.BMC oral health · 2026Trial
- Is ADDM graft practical? A comparative study to evaluate ADDM graft in third molar surgery.Oral and maxillofacial surgery · 2025Trial
- Piezo-surgery technique and intramuscular dexamethasone injection to reduce postoperative pain after impacted mandibular third molar surgery: a randomized clinical trial.BMC oral health · 2021Trial
- Efficacy of methylprednisolone on pain, trismus and quality of life following surgical removal of mandibular third molars: a double-blind, split-mouth, randomised controlled trial.Medicina oral, patologia oral y cirugia bucal · 2021Trial
- Effect of antiseptic gels in the microbiologic colonization of the suture threads after oral surgery.Scientific reports · 2020Trial
- Article
- Anesthetic efficacies of buccal with palatal injection versus buccal with intra-septal injection in permanent maxillary first molars of pediatric patients.Journal of dental anesthesia and pain medicine · 2022Review
- Sub-mucosal Dexamethasone for Post-operative Pain and Oedema Control in Lower Third Molar Surgery.Journal of pharmacy & bioallied sciences · 2022Article
- Effectiveness of dexamethasone or adrenaline with lignocaine 2% for prolonging inferior alveolar nerve block: a randomized controlled trial.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2022Article
- Review of dexamethasone administration for management of complications in postoperative third molar surgery.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2021Review
- Pain in Oral and Maxillofacial Surgery and Implant Dentistry: Types and Management.European journal of dentistry · 2021Article
- Comparative efficiency of the preoperative pterygomandibular space injection of two doses of dexamethasone in mandibular third molar surgery.Journal of dental anesthesia and pain medicine · 2021Article
- Effectiveness of dexamethasone injection in the pterygomandibular space before and after lower third molar surgery.Journal of dental anesthesia and pain medicine · 2020Article
- Dexamethasone Injection Into Pterygomandibular Space Versus Sublingual Space on Post-Operative Sequalae of Lower Third Molar Intervention.Journal of clinical medicine research · 2019Article
- 4% lidocaine versus 4% articaine for inferior alveolar nerve block in impacted lower third molar surgery.Journal of dental anesthesia and pain medicine · 2017Article
- Decreased post-operative pain using a sublingual injection of dexamethasone (8 mg) in lower third molar surgery.Journal of dental anesthesia and pain medicine · 2017Article
- Submucosal Infiltration versus Intravenous Administration of Dexamethasone in Decreasing Post-operative Inflammatory Sequelae after Third Molar Surgery - A Comparative Study.Annals of maxillofacial surgeryArticle
- Salivary Levels of Malondialdehyde and Total Antioxidant Capacity Following Third Molar Surgery - An Evaluative Study.Annals of maxillofacial surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgery on the lower impacted third molar usually involves trauma in the highly vascularized loose connective tissue area, leading to inflammatory sequelae including postoperative pain, swelling, and general oral dysfunction during the immediate post-operative phase. This study aimed to investigate the effectiveness of preoperative injection of a single dose of 8 mg dexamethasone for postoperative pain control in lower third molar surgery.
methodsA controlled, randomized, split-mouth, prospective study involving lower third molar surgery was performed in 31 patients. The randomized sampling group was preoperatively injected, after local anesthesia, with a single dose of dexamethasone (8 mg in 2 ml) through the pterygomandibular space; 2 ml of normal saline (with no dexamethasone) was injected as a placebo.
resultsThe pain VAS score was significantly different on the day of the operation compared to the first post-operative day (P = 0.00 and 0.01, respectively), but it was not significantly different on the third and seventh postoperative day between the control and study groups. There was a significant reduction in swelling on the second postoperative day, and a difference between the second postoperative day and baseline value in the study group (P < 0.05). Trismus was highly significantly different on the second postoperative day and between baseline and second postoperative day between the groups (P = 0.04 and 0.02, respectively). Descriptive statistics and independent-samples t- test were used to assess the significance of differences.
conclusionsInjection of 8 mg dexamethasone into the pterygomandibular space effectively reduced the postoperative pain and other postoperative sequalae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.