Evidence map›Paper›PMID 28879201›Full record

ArticleMolecular neuropsychiatry2017

WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene

Krista M Hennig, Daniel M Fass, Wen-Ning Zhao, Steven D Sheridan, Ting Fu, Serkan Erdin, Alexei Stortchevoi, Diane Lucente, Jannine D Cody, David Sweetser and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular neuropsychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  17. Daughterless, theDisease models & mechanisms · 2020
    Article
  18. Article
  19. Double-Edged Sword of Tumour Suppressor Genes in Schizophrenia.Frontiers in molecular neuroscience · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Krista M HennigChemical Neurobiology Laboratory, Center for Genomic Medicine, Massachusetts General Hospital, Massachusetts, USA.
Daniel M FassChemical Neurobiology Laboratory, Center for Genomic Medicine, Massachusetts General Hospital, Massachusetts, USA.
Wen-Ning ZhaoChemical Neurobiology Laboratory, Center for Genomic Medicine, Massachusetts General Hospital, Massachusetts, USA.
Steven D SheridanChemical Neurobiology Laboratory, Center for Genomic Medicine, Massachusetts General Hospital, Massachusetts, USA.
Ting FuChemical Neurobiology Laboratory, Center for Genomic Medicine, Massachusetts General Hospital, Massachusetts, USA.
Serkan ErdinMolecular Neurogenetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Alexei StortchevoiMolecular Neurogenetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Diane LucenteMolecular Neurogenetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jannine D CodyChromosome 18 Clinical Research Center, Department of Pediatrics, University of Texas Health Sciences Center, San Antonio, Texas, USA.
David SweetserCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
James F GusellaMolecular Neurogenetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Michael E TalkowskiDepartment of Neurology, Harvard Medical School, Boston, Massachusetts, USA.
Stephen J HaggartyChemical Neurobiology Laboratory, Center for Genomic Medicine, Massachusetts General Hospital, Massachusetts, USA.
Harvard University · USMassachusetts General Hospital · USBroad Institute · USThe University of Texas Health Science Center at San Antonio · US

Funding

RAPID GENE DISCOVERYP01GM061354 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI MORTON, CYNTHIA CASSON · 2001 to 2019
$24.3M
Functional Genomics of Neuroplasticity in SchizophreniaR01MH095088 · NIMH · BROAD INSTITUTE, INC. · PI HAGGARTY, STEPHEN J · 2011 to 2014
$2.5M
NIGMS NIH HHS P01 GM061354NIMH NIH HHS R01 MH095088
6 · The paper itself

Abstract

Genetic variation within the transcription factor

Indexed as

Drug discoveryEpigeneticsHistone deacetylasePitt-Hopkins syndromeSchizophreniaTCF4WNT

Identifiers

PMID28879201
PMCPMC5582445
OpenAlexW2734523516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.