ArticleMolecular neuropsychiatry2017
The Nuclear Proteome of White and Gray Matter from Schizophrenia Postmortem Brains.
Article in Molecular neuropsychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Transcriptional Regulators in the Cerebellum in Chronic Schizophrenia: Novel Possible Targets for Pharmacological Interventions.International journal of molecular sciences · 2025Article
- The Roles of hnRNP Family in the Brain and Brain-Related Disorders.Molecular neurobiology · 2024Review
- Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study.Molecular psychiatry · 2024Article
- Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains.Cell & bioscience · 2022Article
- Proteomics and Schizophrenia: The Evolution of a Great Partnership.Advances in experimental medicine and biology · 2022Article
- Postmortem Brains: What Can Proteomics Tell us About the Sources of Schizophrenia?Advances in experimental medicine and biology · 2022Article
- Modeling Schizophrenia In Vitro: Challenges and Insights on Studying Brain Cells.Advances in experimental medicine and biology · 2022Article
- What Can We Learn from Animal Models to Study Schizophrenia?Advances in experimental medicine and biology · 2022Article
- Proteomics for Target Identification in Psychiatric and Neurodegenerative Disorders.Advances in experimental medicine and biology · 2021Article
- The proteome and its dynamics: A missing piece for integrative multi-omics in schizophrenia.Schizophrenia research · 2020Article
- Article
- Biochemical Pathways Triggered by Antipsychotics in Human [corrected] Oligodendrocytes: Potential of Discovering New Treatment Targets.Frontiers in pharmacology · 2019Article
- Review
- Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia.Molecular therapy. Nucleic acids · 2018Article
- Mass spectrometry methods for analysis of extracellular matrix components in neurological diseases.Mass spectrometry reviewsReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia (SCZ) is a serious neuropsychiatric disorder that manifests through several symptoms from early adulthood. Numerous studies over the last decades have led to significant advances in increasing our understanding of the factors involved in SCZ. For example, mass spectrometry-based proteomic analysis has provided important insights by uncovering protein dysfunctions inherent to SCZ. Here, we present a comprehensive analysis of the nuclear proteome of postmortem brain tissues from corpus callosum (CC) and anterior temporal lobe (ATL). We show an overview of the role of deregulated nuclear proteins in these two main regions of the brain: the first, mostly composed of glial cells and axons of neurons, and the second, represented mainly by neuronal cell bodies. These samples were collected from SCZ patients in an attempt to characterize the role of the nucleus in the disease process. With the ATL nucleus enrichment, we found 224 proteins present at different levels, and 76 of these were nuclear proteins. In the CC analysis, we identified 119 present at different levels, and 24 of these were nuclear proteins. The differentially expressed nuclear proteins of ATL are mainly associated with the spliceosome, whereas those of the CC region are associated with calcium/calmodulin signaling.
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