Evidence map›Paper›PMID 28879076›Full record

ArticleRespiratory medicine case reports2017

Immunotherapy "Shock" a case series of PD-L1 100% and pembrolizumab first-line treatment.

Paul Zarogoulidis, Evaggelia Athanasiou, Theodora Tsiouda, Dimitrios Hatzibougias, Haidong Huang, Chong Bai, Georgia Trakada, Lemonia Veletza, Anastasios Kallianos, Christoforos Kosmidis and 5 more

Abstract readCase Reports
In one paragraph

Article in Respiratory medicine case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Cryobiopsy for pneumonitis diagnosis in NSCLC immunotherapy.Respiratory medicine case reports · 2022
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Paul ZarogoulidisPulmonary-Oncology Unit, "Theageneio" Anticancer Hospital, Thessaloniki, Greece.
Evaggelia AthanasiouPrivate Pathology Center, "Microdiagnostics", Thessaloniki, Greece.
Theodora TsioudaPulmonary-Oncology Unit, "Theageneio" Anticancer Hospital, Thessaloniki, Greece.
Dimitrios HatzibougiasPrivate Pathology Center, "Microdiagnostics", Thessaloniki, Greece.
Haidong HuangDepartment of Respiratory and Critical Care Medicine, Shanghai Hospital, Second Military Medical University, Shanghai, China.
Chong BaiDepartment of Respiratory and Critical Care Medicine, Shanghai Hospital, Second Military Medical University, Shanghai, China.
Georgia TrakadaDivision of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.
Lemonia VeletzaDivision of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.
Anastasios KallianosDivision of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.
Christoforos KosmidisSurgery Department, "Interbalkan" European Medical Center, Thessaloniki, Greece.
Nikolaos BarbetakisThoracic Surgery Department, "Theageneio" Anticancer Hospital, Thessaloniki, Greece.
Dimitrios PaliourasThoracic Surgery Department, "Theageneio" Anticancer Hospital, Thessaloniki, Greece.
Aggeliki Rapti2nd Pulmonary Department, "Sotiria" Hospital of Chest Diseases, Athens, Greece.
Dimitrios DrougasPrivate Scientigraphy Department, "Bioiatriki", Thessaloniki, Greece.
Wolfgang Hohenforst-SchmidtSana Clinic Group Franken, Department of Cardiology/Pulmonology/Intensive Care/Nephrology, "Hof" Clinics, University of Erlangen, Hof, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this decade a "bloom" of novel therapies has been observed for non-small cell lung cancer. We have new tools for the diagnosis of lung cancer and also we can re-biospy easier than before in different lesions and obtain tissue samples in order to investigate whether a patient can receive new targeted therapies. Immunotherapy has been well established previously for other forms of cancer, and nowadays it is also available for lung cancer. There are two immunotherapies for now nivolumab and pembrolizumab which can be administered as second line treatment, the second can also be administered as first-line if there is a programmed death-ligand 1 ≥50% expression.

Indexed as

AdenocarcinomaImmunotherapyLung cancerNivolumabPembrolizumabProgrammed death-ligand

Identifiers

PMID28879076
PMCPMC5576975

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.