ArticleRoyal Society open science2017
Tumour heterogeneity promotes collective invasion and cancer metastatic dissemination.
Article in Royal Society open science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- A computational pipeline for spatial mechano-transcriptomics.Nature methods · 2025Article
- A Revised AbaqusMaterials (Basel, Switzerland) · 2024Article
- Spatial heterogeneity in tumor adhesion qualifies collective cell invasion.Biophysical journal · 2024Article
- A Recipe for Successful Metastasis: Transition and Migratory Modes of Ovarian Cancer Cells.Cancers · 2024Review
- Relatively Rare Populations of Invasive Cells Drive Progression of Heterogeneous Tumors.Cellular and molecular bioengineering · 2024Article
- Ferroptosis: a novel strategy to overcome chemoresistance in gynecological malignancies.Frontiers in cell and developmental biology · 2024Review
- Unlocking ovarian cancer heterogeneity: advancing immunotherapy through single-cell transcriptomics.Frontiers in oncology · 2024Review
- Article
- Article
- Cluster size distribution of cells disseminating from a primary tumor.PLoS computational biology · 2021Article
- The landscape of PD-L1 expression and somatic mutations in hepatocellular carcinoma.Journal of gastrointestinal oncology · 2021Article
- Plasticity of cancer cell invasion: Patterns and mechanisms.Translational oncology · 2021Review
- In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition.Nature communications · 2020Article
- Identification of key candidate tumor biomarkers in non-small-cell lung cancer byOncology letters · 2020Article
- The Role of Intra-Tumoral Heterogeneity and Its Clinical Relevance in Epithelial Ovarian Cancer Recurrence and Metastasis.Cancers · 2019Review
- Interrogation of Phenotypic Plasticity between Epithelial and Mesenchymal States in Breast Cancer.Journal of clinical medicine · 2019Article
- A Mathematical Framework for Modelling the Metastatic Spread of Cancer.Bulletin of mathematical biology · 2019Article
- Randomly Distributed K14Cancer research · 2019Article
- Differential molecular markers of primary lung tumors and metastatic sites indicate different possible treatment selections in patients with metastatic lung adenocarcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Article
- Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods.ACS biomaterials science & engineering · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterogeneity within tumour cell populations is commonly observed in most cancers. However, its impact on metastatic dissemination, one of the primary determinants of the disease prognosis, remains poorly understood. Working with a simplified numerical model of tumour spheroids, we investigated the impact of mechanical heterogeneity on the onset of tumour invasion into surrounding tissues. Our work establishes a positive link between tumour heterogeneity and metastatic dissemination, and recapitulates a number of invasion patterns identified
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.