ArticleOpen heart
Pathophysiology of exercise intolerance in chronic diseases: the role of diminished cardiac performance in mitochondrial and heart failure patients.
Article in Open heart. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Brazilian Guideline for Exercise Test in the Adult Population - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Measurement Properties of Aerobic Capacity Measures in Neuromuscular Diseases: A Systematic Review.Journal of rehabilitation medicine · 2022Pooled it
- Tai Chi for cancer survivors: A systematic review toward consensus-based guidelines.Cancer medicine · 2021Pooled it
- Exercise capacity in RYR1-related myopathies.Orphanet journal of rare diseases · 2025Trial
- Impact of continuous vs. interval training on oxygen extraction and cardiac function during exercise in type 2 diabetes mellitus.European journal of applied physiology · 2022Trial
- Reverse cardio-oncology: neuroendocrine axis activation and cardiovascular-disease-derived factors synergistically remodel the tumor microenvironment.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Adherence, Compliance Rates, and Response to Training Among Patients Awaiting Colorectal Cancer Surgery: A Secondary Analysis From the PREHAB Multicentre Trial.Annals of surgical oncology · 2026Article
- The Role of Mechanical Economy and Efficiency as Key Drivers of Cardiac Rehabilitation Exercise Performance Improvement in a Patient With Heart Failure and an Implanted CRT-D: A Case Report and Literature Review.Clinical case reports · 2025Article
- Heterogeneous Exercise Responses to High-Intensity Interval Training Are Associated With Varied Long-Term Cardiovascular Outcomes in Patients With Heart Failure: A 15-Year Follow-Up.Journal of the American Heart Association · 2025Observational
- Monitoring the Effects of Cardiac Rehabilitation Programs in Heart Failure Patients: The Role of Biomarkers.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Review
- Valve cells are crucial for efficient cardiac performance in Drosophila.PLoS genetics · 2025Article
- Correlation of Sit-to-Stand Test and 6-Minute Walk Test to Illustrate Cardiorespiratory Fitness in Systolic Heart Failure Patients.Annals of rehabilitation medicine · 2025Article
- Outcomes misaligned in mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS): implications for trial design.Brain communications · 2025Article
- Haemodynamic determinants of quality of life in chronic heart failure.BMC cardiovascular disorders · 2022Article
- Exercise: a molecular tool to boost muscle growth and mitochondrial performance in heart failure?European journal of heart failure · 2022Review
- Comparison of intrinsic exercise capacity and response to acute exercise in ICR (Institute of Cancer Research) mice derived from three different lineages.Laboratory animal research · 2021Article
- Exercise Testing, Physical Training and Fatigue in Patients with Mitochondrial Myopathy Related to mtDNA Mutations.Journal of clinical medicine · 2021Review
- Genetic variants associated with exercise performance in both moderately trained and highly trained individuals.Molecular genetics and genomics : MGG · 2020Article
- Acceptability, Feasibility and Preliminary Evaluation of a Novel, Personalised, Home-Based Physical Activity Intervention for Chronic Heart Failure (Active-at-Home-HF): a Pilot Study.Sports medicine - open · 2019Article
- Pathophysiology and rehabilitation management of exercise intolerance in COVID-19 patients.Annals of thoracic medicineArticle
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveExercise intolerance is a clinical hallmark of chronic conditions. The present study determined pathophysiological mechanisms of exercise intolerance in cardiovascular, neuromuscular, and metabolic disorders.
methodsIn a prospective cross-sectional observational study 152 patients (heart failure reduced ejection fraction, n=32; stroke, n=34; mitochondrial disease, n=28; type two diabetes, n=28; and healthy controls, n=30) performed cardiopulmonary exercise testing with metabolic and haemodynamic measurements. Peak exercise O
resultsExercise tolerance was significantly diminished in patients compared with controls (ie, by 45% stroke, 39% mitochondria disease, and 33% diabetes and heart failure, p<0.05). Cardiac performance was only significantly reduced in heart failure (due to reduced heart rate, stroke volume, and blood pressure) and mitochondrial patients (due reduced stroke volume) compared with controls (ie, by 53% and 26%, p<0.05). Ability of skeletal muscles to extract oxygen (ie, arterial-venous O
conclusionsDifferent mechanisms explain exercise intolerance in patients with heart failure, mitochondrial dysfunction, stroke and diabetes. Their better understanding may improve management of patients, their stress tolerance and quality of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.