ArticleDiabetology & metabolic syndrome2017
Analysis of factors influencing glucose tolerance in Japanese patients with non-alcoholic fatty liver disease.
Article in Diabetology & metabolic syndrome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 14 citations in OpenAlex.
- A dose-response study of the association between MRI-derived liver proton density fat fraction and prevalent T2DM in postmenopausal women with abnormal glucose metabolism.Frontiers in endocrinology · 2026Article
- Undercarboxylated osteocalcin correlates with insulin secretion in Japanese individuals with diabetes.Diabetology & metabolic syndrome · 2020Article
- Fasting plasma mannose levels are associated with insulin sensitivity independent of BMI in Japanese individuals with diabetes.Diabetology & metabolic syndrome · 2018Article
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Authors and funding
11 authors at 1 institution in 1 country.
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Abstract
backgroundWhile the association of the prevalence of non-alcoholic fatty liver disease (NAFLD) with impaired glucose metabolism has been reported, the factors influencing glucose tolerance in NAFLD remain to be clarified.
methodsGlucose tolerance of 131 Japanese patients diagnosed as NAFLD by histological findings of liver biopsy specimen was examined using 75 g-OGTT. According to Matteoni's classification, patients were divided to 4 groups [M1 ~ 4, M1, 2: non-alcoholic fatty liver (NAFL); and M3, 4: non-alcoholic steatohepatitis (NASH)]. Based on the OGTT data, insulinogenic index (IGI) and QUICKI were calculated as indices of insulin secretion and insulin sensitivity, respectively. Plasma glucose 120 min after glucose loading (G
resultsStepwise multiple regression analysis using G
conclusionImpairment of insulin secretion is the most important factor to predict glucose intolerance in NAFLD; severity of histological findings is associated with insulin sensitivity independent of adiposity in NAFLD.
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