Evidence map›Paper›PMID 28878740›Full record

ArticleFrontiers in microbiology2017

DNA Delivery and Genomic Integration into Mammalian Target Cells through Type IV A and B Secretion Systems of Human Pathogens.

Dolores L Guzmán-Herrador, Samuel Steiner, Anabel Alperi, Coral González-Prieto, Craig R Roy, Matxalen Llosa

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Delivery of functional Cas:DNA nucleoprotein complexes into recipient bacteria through a type IV secretion system.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Review
  4. TheProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Review
  6. Review
  7. TheJournal of bacteriology · 2021
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Dolores L Guzmán-HerradorDepartamento de Biología Molecular, Universidad de Cantabria (UC), Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC, UC-CSIC-SODERCAN)Santander, Spain.
Samuel SteinerDepartment of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New HavenCT, United States.
Anabel AlperiDepartamento de Biología Molecular, Universidad de Cantabria (UC), Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC, UC-CSIC-SODERCAN)Santander, Spain.
Coral González-PrietoDepartamento de Biología Molecular, Universidad de Cantabria (UC), Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC, UC-CSIC-SODERCAN)Santander, Spain.
Craig R RoyDepartment of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New HavenCT, United States.
Matxalen LlosaDepartamento de Biología Molecular, Universidad de Cantabria (UC), Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC, UC-CSIC-SODERCAN)Santander, Spain.
Instituto de Biomedicina y Biotecnología de Cantabria · ESUniversidad de Cantabria · ESYale University · US

Funding

Genetic Analysis of Legionella Phagosome TraffickingR37AI041699 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 2012 to 2021
$5.3M
Genetic Analysis of Legionella Phagosome TraffickingR01AI041699 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 2002 to 2011
$4.1M
Biogenesis of the Coxiella-containing vacuoleR01AI114760 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 2015 to 2019
$2.1M
GENETIC ANALYSIS OF LEGIONELLA PHAGOSOME TRAFFICKINGR29AI041699 · NIAID · YALE UNIVERSITY · PI ROY, CRAIG R. · 1997 to 2001
$277k
NIAID NIH HHS R01 AI041699NIAID NIH HHS R01 AI114760NIAID NIH HHS R29 AI041699NIAID NIH HHS R37 AI041699
6 · The paper itself

Abstract

We explore the potential of bacterial secretion systems as tools for genomic modification of human cells. We previously showed that foreign DNA can be introduced into human cells through the Type IV A secretion system of the human pathogen

Indexed as

bacterial conjugationBartonella henselaeconjugative relaxaseCoxiella burnetiigene therapyintracellular pathogenLegionella pneumophilaprotein secretion

Identifiers

PMID28878740
PMCPMC5572225
OpenAlexW2747464992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.