Evidence map›Paper›PMID 28878677›Full record

ArticleFrontiers in pharmacology2017

Teuvincenone F Suppresses LPS-Induced Inflammation and NLRP3 Inflammasome Activation by Attenuating NEMO Ubiquitination.

Xibao Zhao, Debing Pu, Zizhao Zhao, Huihui Zhu, Hongrui Li, Yaping Shen, Xingjie Zhang, Ruihan Zhang, Jianzhong Shen, Weilie Xiao and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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  8. Tendril extract ofInternational journal of medical sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Xibao ZhaoDepartment of Immunology, School of Medicine, Shenzhen UniversityShenzhen, China.
Debing PuKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan UniversityKunming, China.
Zizhao ZhaoInstitute of Immunology, Department of Basic Medicine, Zhejiang University School of MedicineHangzhou, China.
Huihui ZhuInstitute of Immunology, Department of Basic Medicine, Zhejiang University School of MedicineHangzhou, China.
Hongrui LiDepartment of Immunology, School of Medicine, Shenzhen UniversityShenzhen, China.
Yaping ShenInstitute of Immunology, Department of Basic Medicine, Zhejiang University School of MedicineHangzhou, China.
Xingjie ZhangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan UniversityKunming, China.
Ruihan ZhangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan UniversityKunming, China.
Jianzhong ShenDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn UniversityAuburn, AL, United States.
Weilie XiaoKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan UniversityKunming, China.
Weilin ChenDepartment of Immunology, School of Medicine, Shenzhen UniversityShenzhen, China.
Zhejiang University · CNYunnan University · CNAuburn University · USKunming Institute of Botany · CNShenzhen University · CN

Funding

Non-platelet P2Y Receptor in Vascular Inflammation and ThrombogenesisR01HL125279 · NHLBI · AUBURN UNIVERSITY AT AUBURN · PI SHEN, JIANZHONG · 2017 to 2021
$1.9M
NHLBI NIH HHS R01 HL125279
6 · The paper itself

Abstract

Inflammation causes many diseases that are serious threats to human health. However, the molecular mechanisms underlying regulation of inflammation and inflammasome activation are not fully understood which has delayed the discovery of new anti-inflammatory drugs of urgent clinic need. Here, we found that the natural compound Teuvincenone F, which was isolated and purified from the stems and leaves of

Indexed as

inflammationNEMONLRP3 inflammasometeuvincenone Fubiquitination

Identifiers

PMID28878677
PMCPMC5572209
OpenAlexW2749440584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.