Evidence map›Paper›PMID 28878616›Full record

ArticleFrontiers in neuroscience2017

Interim Results of a Multicenter Trial with the New Electronic Subretinal Implant Alpha AMS in 15 Patients Blind from Inherited Retinal Degenerations.

Katarina Stingl, Ruth Schippert, Karl U Bartz-Schmidt, Dorothea Besch, Charles L Cottriall, Thomas L Edwards, Florian Gekeler, Udo Greppmaier, Katja Kiel, Assen Koitschev and 10 more

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 97 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01024803 nacompletednot on this map

Safety and Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients: A Prospective Multicenter Clinical Study Based on Randomized Intra-individual Implant Activation in Patients With Degenerative Retinal Diseases

TypeinterventionalSponsorRetina Implant AGRan2009 to 2018Enrolled39ConditionsRetinitis Pigmentosa, Retinal DegenerationArmsDevice name: "Retina Implant model Alpha". Surgical implantation of medical device into eye
NCT03561922 naterminatednot on this mapstarted 2018, after this paper: background citation

Impact on Daily Life of Patients Using the Subretinal Implant RETINA IMPLANT Alpha AMS

TypeinterventionalSponsorRetina Implant AGRan2018 to 2019Enrolled2ConditionsRetinal Degeneration, Inherited Retinal Dystrophy Primarily Involving Sensory RetinaArmsRETINA IMPLANT Alpha AMS
NCT03629899 nawithdrawnnot on this mapstarted 2019, after this paper: background citation

Early Feasibility Study of the RETINA IMPLANT Alpha AMS in Blind Patients With Retinitis Pigmentosa

TypeinterventionalSponsorWills EyeRan2019 to 2025Enrolled0ConditionsRetinitis PigmentosaArmsRETINA IMPLANT Alpha AMS
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 1 synthesis or guideline pooled it, 193 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Review
  8. Neural Vision Restoration in Ophthalmology.Annals of biomedical engineering · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Motion perception with visual prostheses.Progress in biomedical engineering (Bristol, England) · 2026
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Restoration of Sight with Electronic Retinal Prostheses.Annual review of vision science · 2025
    Review
  19. Article
  20. Evaluating Deep Human-in-the-Loop Optimization for Retinal Implants Using Sighted Participants.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 2 countries.

Katarina StinglCentre for Ophthalmology, University of TuebingenTuebingen, Germany.
Ruth SchippertRetina Implant AGReutlingen, Germany.
Karl U Bartz-SchmidtCentre for Ophthalmology, University of TuebingenTuebingen, Germany.
Dorothea BeschCentre for Ophthalmology, University of TuebingenTuebingen, Germany.
Charles L CottriallNuffield Laboratory of Ophthalmology, Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, University of OxfordOxford, United Kingdom.
Thomas L EdwardsNuffield Laboratory of Ophthalmology, Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, University of OxfordOxford, United Kingdom.
Florian GekelerCentre for Ophthalmology, University of TuebingenTuebingen, Germany.
Udo GreppmaierRetina Implant AGReutlingen, Germany.
Katja KielStädtisches Klinikum Dresden Friedrichstadt, University Teaching HospitalDresden, Germany.
Assen KoitschevDivision Pediatric Otorhinolaryngology and Otology - Olgahospital, Department of Otorhinolaryngology, Klinikum StuttgartStuttgart, Germany.
Laura KühleweinCentre for Ophthalmology, University of TuebingenTuebingen, Germany.
Robert E MacLarenNuffield Laboratory of Ophthalmology, Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, University of OxfordOxford, United Kingdom.
James D RamsdenNuffield Laboratory of Ophthalmology, Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, University of OxfordOxford, United Kingdom.
Johann RoiderDepartment of Ophthalmology, University of KielKiel, Germany.
Albrecht RothermelInstitute for Microelectronics, University of UlmUlm, Germany.
Helmut SachsStädtisches Klinikum Dresden Friedrichstadt, University Teaching HospitalDresden, Germany.
Greta S SchröderDepartment of Ophthalmology, University of KielKiel, Germany.
Jan TodeDepartment of Ophthalmology, University of KielKiel, Germany.
Nicole TroelenbergRetina Implant AGReutlingen, Germany.
Eberhart ZrennerCentre for Ophthalmology, University of TuebingenTuebingen, Germany.
Kiel University · DEOxford University Hospitals NHS Trust · GBStädtisches Klinikum Dresden · DEUniversity of Oxford · GBKatharinenhospital · DEKlinikum Stuttgart · DESenckenberg Centre for Human Evolution and Palaeoenvironment · DEUniversität Ulm · DE

Funding

Department of Health II-C2-0713-20005
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

artificial visionhereditary retinal diseaseneuroprostheticsphotoreceptor degenerationRETINA IMPLANT Alpha AMSretinitis pigmentosasubretinal implant

Identifiers

PMID28878616
PMCPMC5572402
OpenAlexW2748114767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.