ArticleScientific reports2017
Comparative study on cellular entry of incinerated ancient gold particles (Swarna Bhasma) and chemically synthesized gold particles.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- New Approaches in Breast Cancer Therapy Through Green Nanotechnology and Nano-Ayurvedic Medicine - Pre-Clinical and Pilot Human Clinical Investigations.International journal of nanomedicine · 2020Trial
- Synthesis and Characterization of Triphala-functionalized Gold Nanocomposite and its Anti-proliferative Implications against Liver Cancer.Applied biochemistry and biotechnology · 2026Article
- Preclinical evaluation of Ayurveda and Siddha Herbo-mineral formulations in cancer: A scoping review protocol.PloS one · 2026Article
- Testosterone propionate andInternational journal of reproductive biomedicine · 2023Article
- Nanomaterials in Animal Husbandry: Research and Prospects.Frontiers in genetics · 2022Review
- Cancer-Nano-Interaction: From Cellular Uptake to Mechanobiological Responses.International journal of molecular sciences · 2021Review
- Prospective Application of Nanoparticles Green Synthesized Using Medicinal Plant Extracts as Novel Nanomedicines.Nanotechnology, science and applications · 2021Article
- Ayurvedic metal nanoparticles could be novel antiviral agents against SARS-CoV-2.International nano letters · 2021Review
- Characterization of Rajath Bhasma and Evaluation of Its Toxicity in Zebrafish Embryos and Its Antimicrobial Activity.Journal of microbiology and biotechnology · 2020Article
- Using intracellular plasmonics to characterize nanomorphology in human cells.Microsystems & nanoengineering · 2020Article
- The pervasiveness of macropinocytosis in oncological malignancies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Chemical Compositions of Metals in Bhasmas and Tibetan Zuotai Are a Major Determinant of Their Therapeutic Effects and Toxicity.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Physicochemical Variation in Nanogold-Based Ayurved Medicine Suvarna Bhasma Produced by Various Manufacturers Lead to Different In Vivo Bioaccumulation Profiles.Journal of evidence-based integrative medicineArticle
- Manikya Bhasma is a nanomedicine to affect cancer cell viability through induction of apoptosis.Journal of Ayurveda and integrative medicineArticle
- Assessment of bioavailability of gold bhasma in human participants - A pilot study.Journal of Ayurveda and integrative medicineArticle
- Nanostructured gold in ancient Ayurvedic calcined drug 'swarnabhasma'.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gold nanoparticles (AuNPs) are used for a number of imaging and therapeutic applications in east and western part of the world. For thousands of years, the traditional Indian Ayurvedic approach to healing involves the use of incinerated gold ash, prepared with a variety of plant extracts and minerals depending on the region. Here, we describe the characterization of incinerated gold particles (IAuPs) in HeLa (human cells derived from cervical cancer) and HFF-1 (human foreskin fibroblast cells) in comparison to synthesized citrate-capped gold nanoparticles (AuNPs). We found that while individual IAuP crystallites are around 60 nm in size, they form large aggregates with a mean diameter of 4711.7 nm, some of which can enter cells. Fewer cells appeared to have IAuPs compared to AuNPs, although neither type of particle was toxic to cells. Imaging studies revealed that IAuPs were in vesicles, cytosol, or in the nucleus. We found that their nuclear accumulation likely occurred after nuclear envelope breakdown during cell division. We also found that larger IAuPs entered cells via macropinocytosis, while smaller particles entered via clathrin-dependent receptor-mediated endocytosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.