Evidence map›Paper›PMID 28878348›Full record

ArticleScientific reports2017

FOXF1 transcription factor promotes lung regeneration after partial pneumonectomy.

Craig Bolte, Hannah M Flood, Xiaomeng Ren, Sajjeev Jagannathan, Artem Barski, Tanya V Kalin, Vladimir V Kalinichenko

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Craig BolteCenter for Lung Regenerative Medicine, Cincinnati Children's Research Foundation, Cincinnati, Ohio, USA. Craig.Bolte@cchmc.org.
Hannah M FloodCenter for Lung Regenerative Medicine, Cincinnati Children's Research Foundation, Cincinnati, Ohio, USA.
Xiaomeng RenCenter for Lung Regenerative Medicine, Cincinnati Children's Research Foundation, Cincinnati, Ohio, USA.
Sajjeev JagannathanDivision of Allergy and Immunology, Director of Epigenomics Data Analysis Core, Cincinnati Children's Research Foundation, Cincinnati, Ohio, USA.
Artem BarskiDivision of Allergy and Immunology, Director of Epigenomics Data Analysis Core, Cincinnati Children's Research Foundation, Cincinnati, Ohio, USA.ORCID 0000-0002-1861-5316
Tanya V KalinDivision of Pulmonary Biology, Cincinnati Children's Research Foundation, Cincinnati, Ohio, USA.
Vladimir V KalinichenkoCenter for Lung Regenerative Medicine, Cincinnati Children's Research Foundation, Cincinnati, Ohio, USA. Vladimir.Kalinichenko@cchmc.org.
Cincinnati Children's Hospital Medical Center · US

Funding

Fox Transcription Factors in Development of Pulmonary CapillariesR01HL084151 · NHLBI · UNIVERSITY OF CHICAGO · PI KALINICHENKO, VLADIMIR · 2006 to 2018
$4.9M
Direct Epigenetic Reprogramming of T CellsDP2GM119134 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI BARSKI, ARTEM · 2015 to 2015
$2.3M
Transcriptional regulation of goblet cell metaplasiaR01HL123490 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KALINICHENKO, VLADIMIR · 2014 to 2017
$1.6M
Targeting Foxm1 in pulmonary fibrosisR01HL132849 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KALIN, TANYA · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL084151NHLBI NIH HHS R01 HL123490NHLBI NIH HHS R01 HL132849NIGMS NIH HHS DP2 GM119134
6 · The paper itself

Abstract

FOXF1, a member of the forkhead box family of transcription factors, has been previously shown to be critical for lung development, homeostasis, and injury responses. However, the role of FOXF1 in lung regeneration is unknown. Herein, we performed partial pneumonectomy, a model of lung regeneration, in mice lacking one Foxf1 allele in endothelial cells (PDGFb-iCre/Foxf1

Indexed as

PneumonectomyRegenerationAllelesAnimalsBinding SitesChromatin ImmunoprecipitationEndothelial CellsForkhead Transcription FactorsGene DeletionGene Expression ProfilingHigh-Throughput Nucleotide SequencingLungMatrix Metalloproteinase 14MiceModels, BiologicalNucleotide MotifsForkhead Transcription FactorsFoxf1 protein, mouseMatrix Metalloproteinase 14Tissue Inhibitor of Metalloproteinase-3

Identifiers

PMID28878348
PMCPMC5587533
OpenAlexW2753310465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.