ArticleScientific reports2017
Impact of phenolic compounds in the acyl homoserine lactone-mediated quorum sensing regulatory pathways.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 106 citations in OpenAlex.
- UnderstandingMicroorganisms · 2026Review
- Exploring the effects of phenolic compounds and essential oils in poultry: A sustainable strategy to combat Salmonella biofilm infections.Poultry science · 2025Review
- Multimodal Inhibition ofJournal of agricultural and food chemistry · 2025Article
- The Application of Natural Phenolic Substances as Antimicrobial Agents in Agriculture and Food Industry.Foods (Basel, Switzerland) · 2025Review
- Inhibitory effects of reumycin produced by Streptomyces sp. TPMA0082 on virulence factors of Pseudomonas aeruginosa.Journal of natural medicines · 2025Article
- Anti-biofilm and anti-quorum sensing activities of galloylquinic acid against clinical isolates of multidrug-resistant Pseudomonas aeruginosa in open wound infection: in vitro and in vivo efficacy studies.BMC microbiology · 2025Article
- Quorum Quenching ofPathogens (Basel, Switzerland) · 2025Article
- Article
- Insights into molecular mechanisms of phytochemicals in quorum sensing modulation for bacterial biofilm control.Archives of microbiology · 2024Review
- Anti-Inflammatory, Antibacterial, Anti-Biofilm, and Anti-Quorum Sensing Activities of the Diterpenes Isolated fromPharmaceutics · 2024Article
- Quorum Sensing Inhibitors: An Alternative Strategy to Win the Battle against Multidrug-Resistant (MDR) Bacteria.Molecules (Basel, Switzerland) · 2024Review
- Effect ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Chemical Composition and Quorum Sensing Inhibitory Effect ofJournal of pharmacopuncture · 2023Article
- Inhibition of Pseudomonas aeruginosa quorum sensing by methyl gallate from Mangifera indica.Scientific reports · 2023Article
- Quorum sensing interference by phenolic compounds - A matter of bacterial misunderstanding.Heliyon · 2023Review
- Citrinin Is a Potential Quorum Sensing Inhibitor againstMarine drugs · 2023Article
- Article
- Alkyl Gallates as Potential Antibiofilm Agents: A Review.Molecules (Basel, Switzerland) · 2023Review
- Natural Polyphenols for Prevention and Treatment of Urinary Tract Infections.International journal of molecular sciences · 2023Review
- Future Antimicrobials: Natural and Functionalized Phenolics.Molecules (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quorum sensing (QS) is a cell density-dependent regulation of virulent bacterial gene expression by autoinducers that potentially pertains in the epidemic of bacterial virulence. This study was initially designed to evaluate the effect of 5 phenolic compounds in the modulation of QS and virulence factors of Chromobacterium violaceum and Pseudomonas aeruginosa, and to determine the mechanisms of their effects. Biosensor strains were used to assess antibacterial and anti-QS effect of these compounds. Only methyl gallate (MG) among these compounds demonstrated profound anti-QS effect in the preliminary study, and thus only MG was utilized further to evaluate the effects on the synthesis and activity of acyl homoserine lactone (AHL) in C. violaceum and on the modulation of biofilm, motility, proteolytic, elastase, pyocyanin, and rhamnolipid activity in P. aeruginosa. Finally, the effect of MG on the expression of QS-regulated genes of P. aeruginosa was verified. MG suppressed both the synthesis and activity of AHL in C. violaceum. It also restricted the biofilm formation and other QS-associated virulence factor of P. aeruginosa. MG concentration-dependently suppressed the expression of lasI/R, rhlI/R, and pqsA of P. aeruginosa and was non-toxic in in vitro study. This is the first report of the anti-QS mechanism of MG.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.