ArticleScientific reports2017
The impact of wavelengths of LED light-therapy on endothelial cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- The Effect of Photobiomodulation in the Management of Leg Ulcers in Sickle Cell Disease: A Systematic Review.International wound journal · 2026Pooled it
- A Comprehensive Systematic Review of the Effects of Photobiomodulation Therapy in Different Light Wavelength Ranges (Blue, Green, Red, and Near-Infrared) on Sperm Cell Characteristics in Vitro and in Vivo.Reproductive sciences (Thousand Oaks, Calif.) · 2024Pooled it
- Photobiomodulation at 660 nm enhances proliferative activity while preserving viability in human endothelial cells in vitro.Cell and tissue banking · 2026Article
- Semiconducting Polymer Nanoparticles Enable Light-Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- 630 nm LED phototherapy enhances ovarian function and fertility potential in advanced reproductive age females.Bioengineering & translational medicine · 2026Article
- Label-free assessment of a microfluidic vessel-on-chip model with visible-light optical tomography reveals structural changes in vascular networks.Lab on a chip · 2026Article
- Assessment of Nitric Oxide Release In Vitro via Low-Level Daylight-Equivalent Blue or Red Light Irradiation.Antioxidants (Basel, Switzerland) · 2026Article
- Mitochondrial fatty acid oxidation is stimulated by red light irradiation.FEBS letters · 2026Article
- Adipose-Derived Stem Cells Pretreated With Phototherapy Promote HUVECs Migration and Angiogenesis by Mediating EYA1 Activation.Physiological research · 2025Article
- Investigation of the effect of photobiomodulation therapy with different wavelengths on nerve regeneration: an experimental study.BMC oral health · 2025Article
- Article
- Photobiomodulatory Effects of Low-Power LED Light on Cultured Human Umbilical Vein Endothelial Cells.Journal of clinical medicine · 2025Article
- Optical analysis for effective phototherapy in an LED oral care device.Biomedical optics express · 2025Article
- Shining light on chest shielding.Pediatric research · 2024Article
- Natural Phytochemical and Visible Light at Different Wavelengths Show Synergistic Antibacterial Activity againstPharmaceutics · 2024Article
- Photobiomodulation therapy's impact on angiogenesis and osteogenesis in orthodontic tooth movement: in vitro and in vivo study.BMC oral health · 2024Article
- Photo-Chemical Stimulation of Neurons with Organic Semiconductors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Efficacy of lidocaine wet compress combined with red-light irradiation for chronic wounds.World journal of clinical cases · 2023Article
- Effects of Different Spectrum of LEDs on Retinal Degeneration Through Regulating Endoplasmic Reticulum Stress.Translational vision science & technology · 2023Article
- Fortifying angiogenic efficacy of conditioned media using phototoxic-free blue light for wound healing.Bioengineering & translational medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low level light therapy receives increasing interest in the fields of tissue regeneration and wound healing. Several in vivo studies demonstrated the positive effects of LLLT on angiogenesis. This study aimed to investigate the underlying properties in vitro by comparing the effects of light therapy by light emitting diodes of different wavelengths on endothelial cells in vitro. Human umbilical vein endothelial cells were treated with either 475 nm, 516 nm or 635 nm light. Control cells were not illuminated. 2D proliferation was quantified by manual counting. HUVEC migration was analyzed by performing a 2D wound scratch assay and a 3D bead assay. The influence of LLLT on early vasculogenic events was determined in a 3D fibrin co-culture model with adipose-derived stem cells. Stimulation with both red and green pulsed LED light significantly increased HUVEC proliferation and 3D migration. Moreover, HUVEC showed increased 2D migration potential with green light stimulation. The treatment with blue light was ineffective. Several parameters showed that green light was even more potent to stimulate proliferation and migration of endothelial cells than clinically well-established red light therapy. Further studies have to focus on intracellular mechanisms induced by different wavelengths in order to optimize this promising therapy in tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.