ArticleNature communications2017
Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Highly selective enrichment of multi-phosphopeptides by polyurea-modified macroporous adsorption resin via hydrogen-bond-mediated interaction.Mikrochimica acta · 2026Article
- Article
- In-Tip Nanoreactors for Simultaneous Proteolysis and Enrichment of Phosphorylated Peptides.Analytical science advances · 2025Article
- A cerium phthalocyanine-based covalent organic framework-magnetic core-shell composite as efficient affinity material for the enrichment of phosphopeptides.Mikrochimica acta · 2025Article
- Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges.ACS applied materials & interfaces · 2025Review
- Polymers for Disrupting Protein-Protein Interactions: Where Are We and Where Should We Be?Biomacromolecules · 2024Review
- [Progress in enrichment methods for proteinSe pu = Chinese journal of chromatography · 2024Review
- Monodisperse TiMikrochimica acta · 2022Article
- [Application of smart responsive materials in phosphopeptide and glycopeptide enrichment].Se pu = Chinese journal of chromatography · 2022Review
- A novel graphene oxide/chitosan foam incorporated with metal-organic framework stationary phase for simultaneous enrichment of glycopeptide and phosphopeptide with high efficiency.Analytical and bioanalytical chemistry · 2022Article
- A Two-Dimensional Metallacycle Cross-Linked Switchable Polymer for Fast and Highly Efficient Phosphorylated Peptide Enrichment.Journal of the American Chemical Society · 2021Article
- Optical chemosensors for the detection of proximally phosphorylated peptides and proteins.RSC chemical biology · 2021Review
- [Advances in enrichment of phosphorylated peptides and glycopeptides by smart polymer-based materials].Se pu = Chinese journal of chromatography · 2021Review
- AuNational science review · 2020Article
- Does Oxygen Feature Chalcogen Bonding?Molecules (Basel, Switzerland) · 2019Article
- Smart polymers driven by multiple and tunable hydrogen bonds for intact phosphoprotein enrichment.Science and technology of advanced materials · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multisite phosphorylation is an important and common mechanism for finely regulating protein functions and subsequent cellular responses. However, this study is largely restricted by the difficulty to capture low-abundance multiply phosphorylated peptides (MPPs) from complex biosamples owing to the limitation of enrichment materials and their interactions with phosphates. Here we show that smart polymer can serve as an ideal platform to resolve this challenge. Driven by specific but tunable hydrogen bonding interactions, the smart polymer displays differential complexation with MPPs, singly phosphorylated and non-modified peptides. Importantly, MPP binding can be modulated conveniently and precisely by solution conditions, resulting in highly controllable MPP adsorption on material surface. This facilitates excellent performance in MPP enrichment and separation from model proteins and real biosamples. High enrichment selectivity and coverage, extraordinary adsorption capacities and recovery towards MPPs, as well as high discovery rates of unique phosphorylation sites, suggest its great potential in phosphoproteomics studies.Capture of low-abundance multiply phosphorylated peptides (MPPs) is difficult due to limitation of enrichment materials and their interactions with phosphates. Here the authors show, a smart polymer driven by specific but tunable hydrogen bonding interactions can differentially complex with MPPs, singly phosphorylated and non-modified peptides.
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