ArticleScientific reports2017
In-line balanced detection stimulated Raman scattering microscopy.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Simultaneous dual-Raman-shift scanning-free stimulated Raman scattering microscopy for label-free biomolecular imaging.Nature communications · 2026Article
- Improved Dual-Modality Bioequivalence Evaluation of Topical Formulations Within Human Skin Using Stimulated Raman Scattering Microscopy.Pharmaceutics · 2025Article
- Advanced vibrational microscopes for life science.Nature methods · 2025Review
- Noninvasive morpho-molecular imaging reveals early therapy-induced senescence in human cancer cells.Science advances · 2023Article
- Label-free multimodal nonlinear optical microscopy reveals features of bone composition in pathophysiological conditions.Frontiers in bioengineering and biotechnology · 2022Article
- Multiwindow SRS Imaging Using a Rapid Widely Tunable Fiber Laser.Analytical chemistry · 2021Article
- Broadband stimulated Raman scattering microscopy with wavelength-scanning detection.Journal of Raman spectroscopy : JRS · 2020Article
- Adaptive noise canceling for transient absorption microscopy.Journal of biomedical optics · 2020Article
- Simultaneous stimulated Raman gain and loss detection (SRGAL).Optics express · 2020Article
- Nonlinear Optical Microscopy: From Fundamentals to Applications in Live Bioimaging.Frontiers in bioengineering and biotechnology · 2020Review
- Lipid accumulation in human breast cancer cells injured by iron depletors.Journal of experimental & clinical cancer research : CR · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We introduce a novel configuration for stimulated Raman scattering (SRS) microscopy, called In-line Balanced Detection (IBD), which employs a birefringent plate to generate a time-delayed polarization-multiplexed collinear replica of the probe, acting as a reference. Probe and reference cross the sample at the same position, thus maintaining their balance during image acquisition. IBD can be implemented in any conventional SRS setup, by adding a few simple elements, bringing its sensitivity close to the shot-noise limit even with a noisy laser. We tested IBD with a fiber-format laser system and observed signal-to-noise ratio improvement by up to 30 dB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.