ArticleScientific reports2017
Respiratory oscillations in alveolar oxygen tension measured in arterial blood.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- Computer model coupling hemodynamics and oxygen transport in the coronary capillary network: Pulsatile vs. non-pulsatile analysis.Computer methods and programs in biomedicine · 2025Article
- Exposure to Non-Steady-State Oxygen Is Reflected in Changes to Arterial Blood Gas Values, Prefrontal Cortical Activity, and Systemic Cytokine Levels.International journal of molecular sciences · 2024Article
- Could respiration-driven blood oxygen changes modulate neural activity?Pflugers Archiv : European journal of physiology · 2023Review
- Mathematically arterialised venous blood is a stable representation of patient acid-base status at steady state following acute transient changes in ventilation.Journal of clinical monitoring and computing · 2022Article
- Bedside monitoring of lung volume available for gas exchange.Intensive care medicine experimental · 2021Article
- Mechanical Ventilation Redistributes Blood to Poorly Ventilated Areas in Experimental Lung Injury.Critical care medicine · 2020Article
- Real-time effects of PEEP and tidal volume on regional ventilation and perfusion in experimental lung injury.Intensive care medicine experimental · 2020Article
- Investigating Disturbances of Oxygen Homeostasis: From Cellular Mechanisms to the Clinical Practice.Frontiers in physiology · 2020Review
- Cerebral oxygenation during locomotion is modulated by respiration.Nature communications · 2019Article
- Dynamic single-slice CT estimates whole-lung dual-energy CT variables in pigs with and without experimental lung injury.Intensive care medicine experimental · 2019Article
- Noninvasive cardiac output monitoring in a porcine model using the inspired sinewave technique: a proof-of-concept study.British journal of anaesthesia · 2019Article
- Tidal changes in PaOBritish journal of anaesthesia · 2019Article
- Gas Partial Pressure in Cultured Cells: Patho-Physiological Importance and Methodological Approaches.Frontiers in physiology · 2018Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Arterial oxygen partial pressure can increase during inspiration and decrease during expiration in the presence of a variable shunt fraction, such as with cyclical atelectasis, but it is generally presumed to remain constant within a respiratory cycle in the healthy lung. We measured arterial oxygen partial pressure continuously with a fast intra-vascular sensor in the carotid artery of anaesthetized, mechanically ventilated pigs, without lung injury. Here we demonstrate that arterial oxygen partial pressure shows respiratory oscillations in the uninjured pig lung, in the absence of cyclical atelectasis (as determined with dynamic computed tomography), with oscillation amplitudes that exceeded 50 mmHg, depending on the conditions of mechanical ventilation. These arterial oxygen partial pressure respiratory oscillations can be modelled from a single alveolar compartment and a constant oxygen uptake, without the requirement for an increased shunt fraction during expiration. Our results are likely to contribute to the interpretation of arterial oxygen respiratory oscillations observed during mechanical ventilation in the acute respiratory distress syndrome.
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Registered trials
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