ArticleNature communications2017
Community-like genome in single cells of the sulfur bacterium Achromatium oxaliferum.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
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- Global dominance of Haloquadratum walsbyi by a single genomovar with distinct gene content and viral cohorts from close relatives.The ISME journal · 2025Article
- Intermolecular Gene Conversion for the Equalization of Genome Copies in the Polyploid HaloarchaeonGenes · 2024Article
- One Advantage of Being Polyploid: Prokaryotes of Various Phylogenetic Groups Can Grow in the Absence of an Environmental Phosphate Source at the Expense of Their High Genome Copy Numbers.Microorganisms · 2023Article
- Genomic Mysteries of Giant Bacteria: Insights and Implications.Genome biology and evolution · 2023Article
- Ploidy inGenes · 2023Review
- DoriC 12.0: an updated database of replication origins in both complete and draft prokaryotic genomes.Nucleic acids research · 2023Article
- Ori-Finder 2022: A Comprehensive Web Server for Prediction and Analysis of Bacterial Replication Origins.Genomics, proteomics & bioinformatics · 2022Article
- Fixation dynamics of beneficial alleles in prokaryotic polyploid chromosomes and plasmids.Genetics · 2022Article
- Non-equivalent genomes in polyploid prokaryotes.Nature microbiology · 2022Article
- Heterozygous, Polyploid, Giant Bacterium, Achromatium, Possesses an Identical Functional Inventory Worldwide across Drastically Different Ecosystems.Molecular biology and evolution · 2021Article
- Rates of gene conversions between Escherichia coli ribosomal operons.G3 (Bethesda, Md.) · 2021Article
- Factors That Affect the Enlargement of Bacterial Protoplasts and Spheroplasts.International journal of molecular sciences · 2020Review
- Detection of mixed-strain infections by FACS and ultra-low input genome sequencing.Gut microbes · 2020Article
- Cell Architecture of the Giant Sulfur Bacterium Achromatium oxaliferum: Extra-cytoplasmic Localization of Calcium Carbonate Bodies.FEMS microbiology ecology · 2020Article
- A Crispy Diet: Grazers of Achromatium oxaliferum in Lake Stechlin Sediments.Microbial ecology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyploid bacteria are common, but the genetic and functional diversity resulting from polyploidy is unknown. Here we use single-cell genomics, metagenomics, single-cell amplicon sequencing, and fluorescence in situ hybridization, to show that individual cells of Achromatium oxaliferum, the world's biggest known freshwater bacterium, harbor genetic diversity typical of whole bacterial communities. The cells contain tens of transposable elements, which likely cause the unprecedented diversity that we observe in the sequence and synteny of genes. Given the high within-cell diversity of the usually conserved 16S ribosomal RNA gene, we suggest that gene conversion occurs in multiple, separated genomic hotspots. The ribosomal RNA distribution inside the cells hints to spatially differential gene expression. We also suggest that intracellular gene transfer may lead to extensive gene reshuffling and increased diversity.The cells of Achromatium bacteria are remarkably large and contain multiple chromosome copies. Here, Ionescu et al. show that chromosome copies within individual cells display high diversity, similar to that of bacterial communities, and contain tens of transposable elements.
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