Evidence map›Paper›PMID 28878204›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2017

Analysis of Antineutrophil Cytoplasm Antibody from 118 730 Patients in Tertiary Hospitals in Jiangxi Province, China.

Liming Tan, Anjun Jiao, Juanjuan Chen, Xiaojing Feng, Liuyue Xu, Siqi He, Fuyan Tan, Yongqing Jiang, Heng Luo, Hua Li and 18 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
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Article in Medical science monitor : international medical journal of experimental and clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

28 authors at 7 institutions in 1 country.

Liming TanDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Anjun JiaoSchool of Public Health, Nanchang University, Nanchang, Jiangxi, China (mainland).
Juanjuan ChenDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Xiaojing FengSchool of Public Health, Nanchang University, Nanchang, Jiangxi, China (mainland).
Liuyue XuSchool of Public Health, Nanchang University, Nanchang, Jiangxi, China (mainland).
Siqi HeSchool of Public Health, Nanchang University, Nanchang, Jiangxi, China (mainland).
Fuyan TanSchool of Public Health, Nanchang University, Nanchang, Jiangxi, China (mainland).
Yongqing JiangDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Heng LuoDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Hua LiDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Yang WuDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Yongjian TianDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Tingting ZengDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Jianlin YuDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Liping CaoDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Jianfeng ZhengDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Hui XuDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Ming WeiDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Wen GanDepartment of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Weihua PengDepartment of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
Yanming LiuDepartment of Clinical Laboratory, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China (mainland).
Jing HouDepartment of Clinical Laboratory, Jiangxi Provincial Hospital of Traditional Chinese Medicine, Nanchang, Jiangxi, China (mainland).
Jiangxia XuDepartment of Clinical Laboratory, The Fourth Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
LiHua ShuaiDepartment of Clinical Laboratory, The Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, China (mainland).
Wenzhi HuangDepartment of Clinical Laboratory, Yichun People's Hospital of Jiangxi Province, Yichun, Jiangxi, China (mainland).
Junyun HuangDepartment of Clinical Laboratory, Yichun People's Hospital of Jiangxi Province, Yichun, Jiangxi, China (mainland).
Yan LinDepartment of Clinical Laboratory, Ganzhou People's Hospital of Jiangxi Province, Ganzhou, Jiangxi, China (mainland).
Jianrong LiuDepartment of Clinical Laboratory, Pingxiang People's Hospital of Jiangxi Province, Pingxiang, Jiangxi, China (mainland).
Nanchang University · CNSecond Affiliated Hospital of Nanchang University · CNYichun University · CNGanzhou People's Hospital · CNJiangxi Pingxiang People's Hospital · CNJiangxi Provincial People's Hospital · CNJiujiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND The discovery of antineutrophil cytoplasm antibody (ANCA) makes the early diagnosis of primary vasculitis possible, and also has important guiding significance for the diagnosis and treatment of secondary vasculitis. This study aimed to investigate the clinical significance of ANCA. MATERIAL AND METHODS ANCA was detected by indirect immunofluorescence assay (IIF), and anti-myeloperoxidase (MPO) antibody, and anti-proteinase 3 (PR3) antibody were detected by ELISA. The results were analyzed retrospectively. RESULTS Among 118 730 patients, a total of 5853 (4.93%) were positive for ANCA. In the positive cases, 3.98% were male and 6.33% were female, with significant differences (χ²=123.38, P<0.01). For ANCA, the department with the highest positive rate (15.06%) was the Department of Rheumatology, followed by 7.78% in the Department of Dermatology, 6.79% in the Department of Nephrology, and 5.72% in the Department of Traditional Chinese Medicine (TCM). Anti-PR3 and cANCA were highly specific in primary vasculitis (P<0.01). Anti-MPO and pANCA had high specificity for other autoimmune diseases (P<0.01). CONCLUSIONS ANCA has important guiding significance for vasculitis-related diseases. Therefore, it is important in the diagnosis and treatment of this disease and has value in clinical practice.

Indexed as

AdultAntibodies, Antineutrophil CytoplasmicChinaFemaleFluorescent Antibody Technique, IndirectHumansMaleMiddle AgedRetrospective StudiesTertiary Care CentersVasculitisAntibodies, Antineutrophil Cytoplasmic

Identifiers

PMID28878204
PMCPMC5600193
OpenAlexW2753482521

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.