Evidence map›Paper›PMID 28878194›Full record

ArticleBiosensors2017

A Rationally Designed Reversible 'Turn-Off' Sensor for Glutathione.

Sabrina Heng, Xiaozhou Zhang, Jinxin Pei, Andrew D Abell

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sabrina HengARC Centre of Excellence for Nanoscale BioPhotonics, Institute of Photonics and Advanced Sensing, Department of Chemistry, School of Physical Sciences, The University of Adelaide, Adelaide SA 5005, Australia. sabrina.heng@adelaide.edu.au.ORCID 0000-0002-2008-2790
Xiaozhou ZhangARC Centre of Excellence for Nanoscale BioPhotonics, Institute of Photonics and Advanced Sensing, Department of Chemistry, School of Physical Sciences, The University of Adelaide, Adelaide SA 5005, Australia. xiao.z.zhang@adelaide.edu.au.
Jinxin PeiDiscipline of Physiology, Faculty of Health Sciences, The University of Adelaide, Adelaide SA 5005, Australia. jinxin.pei@adelaide.edu.au.
Andrew D AbellARC Centre of Excellence for Nanoscale BioPhotonics, Institute of Photonics and Advanced Sensing, Department of Chemistry, School of Physical Sciences, The University of Adelaide, Adelaide SA 5005, Australia. andrew.abell@adelaide.edu.au.
The University of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γ-Glutamyl-cysteinyl-glycine (GSH) plays a critical role in maintaining redox homeostasis in biological systems and a decrease in its cellular levels is associated with diseases. Existing fluorescence-based chemosensors for GSH acts as irreversible reaction-based probes that exhibit a maximum fluorescence ('turn-on') once the reaction is complete, regardless of the actual concentration of GSH. A reversible, reaction-based 'turn-off' probe (

Indexed as

BenzopyransBiosensing TechniquesFluorescent DyesGlutathioneHEK293 CellsHumansIndolesNitro CompoundsBenzopyransFluorescent DyesGlutathioneIndolesmerocyanineNitro Compoundsspiropyranfluorescent sensorintracellular sensingphotoswitchreduced glutathionereversible sensorspiropyranturn-off sensor

Identifiers

PMID28878194
PMCPMC5618042
OpenAlexW2752680494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.