Evidence map›Paper›PMID 28878089›Full record

Trial reportJournal of virology2017

HLA-B*14:02-Restricted Env-Specific CD8

Ellen M Leitman, Christian B Willberg, Ming-Han Tsai, Huabiao Chen, Søren Buus, Fabian Chen, Lynn Riddell, David Haas, Jacques Fellay, James J Goedert and 13 more

Open access · hybridAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. The influence of HLA/HIV genetics on the occurrence of elite controllers and a need for therapeutics geotargeting view.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 16 institutions in 6 countries.

Ellen M LeitmanDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom ellen_leitman@hms.harvard.edu.
Christian B WillbergNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Ming-Han TsaiDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom.
Huabiao ChenRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Søren BuusLaboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Fabian ChenDepartment of Sexual Health, Royal Berkshire Hospital, Reading, United Kingdom.
Lynn RiddellIntegrated Sexual Health Services, Northamptonshire Healthcare NHS Trust, Northampton, United Kingdom.
David HaasDepartments of Medicine, Pharmacology, Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Jacques FellaySchool of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Swiss Institute of Bioinformatics, Lausanne, Switzerland.
James J GoedertInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Alicja Piechocka-TrochaRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Bruce D WalkerRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Jeffrey MartinDepartment of Medicine, University of California San Francisco Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Steven DeeksDepartment of Medicine, University of California, San Francisco, California, USA.
Steven M WolinskyNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Jeremy MartinsonDepartment of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Maureen MartinCancer and Inflammation Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Ying QiCancer and Inflammation Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Asier Sáez-CiriónInstitut Pasteur, Unité HIV, Inflammation et Persistance, Paris, France.ORCID http://orcid.org/0000-0003-2406-7536
Otto O YangDepartment of Medicine, Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Philippa C MatthewsNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Mary CarringtonRagon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Philip J R GoulderDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom.
Leidos (United States) · USUniversity of Oxford · GBHarvard University · USRagon Institute of MGH, MIT and Harvard · USUniversity of California, San Francisco · USAIDS Healthcare Foundation · USInstitut Pasteur · FRJohn Radcliffe Hospital · GBNational Institutes of Health · USNorthamptonshire Healthcare NHS Foundation Trust · GBNorthwestern University · USRoyal Berkshire Hospital · GBSIB Swiss Institute of Bioinformatics · CHUniversity of Copenhagen · DKUniversity of Pittsburgh · USVanderbilt University · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 1988 to 2026
$93.6M
NATURAL HISTORY OF AIDS IN HOMOSEXUAL MENU01AI035040 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DETELS, ROGER, MARTINEZ-MAZA, OTONIEL · 1993 to 2018
$75.2M
University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
Center for the Analysis & Management of the Multicenter AIDS Cohort StudyUM1AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI D'SOUZA, GYPSYAMBER, JACOBSON, LISA P · 2012 to 2018
$20.7M
Pharmacogenomics of HIV TherapyR01AI077505 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAAS, DAVID W · 2008 to 2025
$12.3M
Optimizing CD8+ T-cell responses against C clade HIV infection in subSaharan AfriR01AI046995 · NIAID · UNIVERSITY OF OXFORD · PI GOULDER, PHILIP J · 2000 to 2014
$6.8M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI046995NIAID NIH HHS R01 AI077505NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035040NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS UM1 AI035043Wellcome Trust
6 · The paper itself

Abstract

Immune control of human immunodeficiency virus type 1 (HIV) infection is typically associated with effective Gag-specific CD8

Indexed as

Immunity, CellularAdultCD8-Positive T-Lymphocytesgag Gene Products, Human Immunodeficiency VirusHIV-1HIV Envelope Protein gp160HIV InfectionsHLA-B14 AntigenHumansPeptidesgag Gene Products, Human Immunodeficiency VirusHIV Envelope Protein gp160HLA-B*14:01 antigenHLA-B*14:02 antigenHLA-B14 AntigenPeptidesCD8+ T cellsHIVHLA-B*14immune control

Identifiers

PMID28878089
PMCPMC5660483
OpenAlexW2750596791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.