ArticleProceedings of the National Academy of Sciences of the United States of America2017
Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- The effect of fecal bile acids on the incidence and risk-stratification of colorectal cancer: an updated systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Cholecystectomy promotes the development of colorectal cancer by the alternation of bile acid metabolism and the gut microbiota.Frontiers in medicine · 2022Pooled it
- Long-term risk of colorectal cancer following cholecystectomy: a nationwide cohort study.Surgical endoscopy · 2026Article
- Cholecystectomy-induced gut dysbiosis and its consequences: bridging animal models and clinical outcomes in narrative review.Translational gastroenterology and hepatology · 2026Review
- Limited effect of surfactant protein D ablation on doxorubicin-induced intestinal toxicity in mice.Frontiers in immunology · 2026Article
- Gut-engineeredFrontiers in bioengineering and biotechnology · 2026Article
- Review
- Analysis of the effect of the Xianglian capsule on patients with diarrhea after cholecystectomy: a protocol for a single-center, randomized controlled trial.BMC complementary medicine and therapies · 2025Article
- What defines a healthy gut microbiome?Gut · 2024Review
- Soluble Human Lectins at the Host-Microbe Interface.Annual review of biochemistry · 2024Review
- Analysis of quality of life in patients after transgastric natural orifice transluminal endoscopic gallbladder-preserving surgery.World journal of gastrointestinal endoscopy · 2024Article
- Lectin-Seq: A method to profile lectin-microbe interactions in native communities.Science advances · 2023Article
- Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.The Journal of experimental medicine · 2023Article
- Does postcholecystectomy increase the risk of colorectal cancer?Frontiers in microbiology · 2023Review
- Surfactant Protein D Influences Mortality During Abdominal Sepsis by FacilitatingCritical care explorations · 2022Article
- Progress in the Study of Colorectal Cancer Caused by Altered Gut Microbiota After Cholecystectomy.Frontiers in endocrinology · 2022Review
- Cholecystectomy as a risk factor for metabolic dysfunction-associated fatty liver disease: unveiling the metabolic and chronobiologic clues behind the bile acid enterohepatic circulation.Journal of physiology and biochemistry · 2021Review
- Proteomic analysis of the host-pathogen interface in experimental cholera.Nature chemical biology · 2021Article
- Association between SP-A rs1965708 gene polymorphism and allergic rhinitis risk in Chinese population.Journal of clinical laboratory analysis · 2021Article
- Bile Acids and Microbiota: Multifaceted and Versatile Regulators of the Liver-Gut Axis.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The commensal microbiota within the gastrointestinal tract is essential in maintaining homeostasis. Indeed, dysregulation in the repertoire of microbiota can result in the development of intestinal immune-inflammatory diseases. Further, this immune regulation by gut microbiota is important systemically, impacting health and disease of organ systems beyond the local environment of the gut. What has not been explored is how distant organs might in turn shape the microbiota via microbe-targeted molecules. Here, we provide evidence that surfactant protein D (SP-D) synthesized in the gallbladder and delivered into intestinal lumen binds selectively to species of gut commensal bacteria. SP-D-deficient mice manifest intestinal dysbiosis and show a susceptibility to dextran sulfate sodium-induced colitis. Further, fecal transfer from SP-D-deficient mice to wild-type, germ-free mice conveyed colitis susceptibility. Interestingly, colitis caused a notable increase in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.