Evidence map›Paper›PMID 28878013›Full record

ArticleScience translational medicine2017

New class of precision antimicrobials redefines role of

Joseph A Kirk, Dana Gebhart, Anthony M Buckley, Stephen Lok, Dean Scholl, Gillian R Douce, Gregory R Govoni, Robert P Fagan

Abstract read
In one paragraph

Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 90 citations in OpenAlex.

  1. Review
  2. Review
  3. Collective fluctuations underlying nanobody inhibitory activity targetingbioRxiv : the preprint server for biology · 2026
    Article
  4. Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026
    Review
  5. Article
  6. Analysis of essential genes inJournal of bacteriology · 2025
    Article
  7. Review
  8. Cryo-EM structure and polar assembly of the PS2 S-layer ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Analysis of Essential Genes inbioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Clinical microbiology reviews · 2024
    Review
  13. Article
  14. Identification ofJournal of bacteriology · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Joseph A KirkKrebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.ORCID http://orcid.org/0000-0002-8117-8120
Dana GebhartAvidBiotics Corp., South San Francisco, CA 94080, USA.ORCID http://orcid.org/0000-0003-1564-8515
Anthony M BuckleyInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Stephen LokAvidBiotics Corp., South San Francisco, CA 94080, USA.
Dean SchollAvidBiotics Corp., South San Francisco, CA 94080, USA.
Gillian R DouceInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.ORCID http://orcid.org/0000-0002-6654-7346
Gregory R GovoniAvidBiotics Corp., South San Francisco, CA 94080, USA. ggovons@gmail.com r.fagan@sheffield.ac.uk.ORCID http://orcid.org/0000-0002-4664-0834
Robert P FaganKrebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK. ggovons@gmail.com r.fagan@sheffield.ac.uk.ORCID http://orcid.org/0000-0002-8704-4828
AvidBiotics (United States) · USUniversity of Glasgow · GBUniversity of Sheffield · GB

Funding

Development of Modified R-type Bacteriocins to Specifically Target C. difficile and Prevent Relapse of CDIsR21AI121692 · NIAID · AVIDBIOTICS CORPORATION · PI SCHOLL, DEAN M · 2016 to 2017
$444k
Medical Research Council MR/N000900/1NIAID NIH HHS R21 AI121692Wellcome Trust 086418
6 · The paper itself

Abstract

There is a medical need for antibacterial agents that do not damage the resident gut microbiota or promote the spread of antibiotic resistance. We recently described a prototypic precision bactericidal agent, Av-CD291.2, which selectively kills specific

Indexed as

AllelesAmino Acid SequenceAnimalsAnti-Infective AgentsBacteriocinsClostridioides difficileColony Count, MicrobialCricetinaeDrug Resistance, BacterialGastrointestinal TractImmunity, InnateMembrane GlycoproteinsMicrobial ViabilityMutationPhenotypeSpores, BacterialAnti-Infective AgentsavidocinBacteriocinsMembrane GlycoproteinsS-layer proteinsToxins, Biological

Identifiers

PMID28878013
PMCPMC5603275
OpenAlexW2751560363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.