Evidence map›Paper›PMID 28877975›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2017

The lung in amyloidosis.

Paolo Milani, Marco Basset, Francesca Russo, Andrea Foli, Giovanni Palladini, Giampaolo Merlini

Abstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 1 synthesis or guideline pooled it.

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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paolo MilaniAmyloidosis Research and Treatment Centre, Foundation IRCCS Policlinico San Matteo and Dept of Molecular Medicine, University of Pavia, Pavia, Italy.
Marco BassetAmyloidosis Research and Treatment Centre, Foundation IRCCS Policlinico San Matteo and Dept of Molecular Medicine, University of Pavia, Pavia, Italy.
Francesca RussoAmyloidosis Research and Treatment Centre, Foundation IRCCS Policlinico San Matteo and Dept of Molecular Medicine, University of Pavia, Pavia, Italy.
Andrea FoliAmyloidosis Research and Treatment Centre, Foundation IRCCS Policlinico San Matteo and Dept of Molecular Medicine, University of Pavia, Pavia, Italy.
Giovanni PalladiniAmyloidosis Research and Treatment Centre, Foundation IRCCS Policlinico San Matteo and Dept of Molecular Medicine, University of Pavia, Pavia, Italy.
Giampaolo MerliniAmyloidosis Research and Treatment Centre, Foundation IRCCS Policlinico San Matteo and Dept of Molecular Medicine, University of Pavia, Pavia, Italy gmerlini@unipv.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloidosis is a disorder caused by misfolding of autologous protein and its extracellular deposition as fibrils, resulting in vital organ dysfunction and eventually death. Pulmonary amyloidosis may be localised or part of systemic amyloidosis.Pulmonary interstitial amyloidosis is symptomatic only if the amyloid deposits severely affect gas exchange alveolar structure, thus resulting in serious respiratory impairment. Localised parenchymal involvement may be present as nodular amyloidosis or as amyloid deposits associated with localised lymphomas. Finally, tracheobronchial amyloidosis, which is usually not associated with evident clonal proliferation, may result in airway stenosis.Because the treatment options for amyloidosis are dependent on the fibril protein type, the workup of all new cases should include accurate determination of the amyloid protein. Most cases are asymptomatic and need only a careful follow-up. Diffuse alveolar-septal amyloidosis is treated according to the underlying systemic amyloidosis. Nodular pulmonary amyloidosis is usually localised, conservative excision is usually curative and the long-term prognosis is excellent. Tracheobronchial amyloidosis is usually treated with bronchoscopic interventions or external beam radiation therapy.

Indexed as

AmyloidosisAnimalsHumansLungLung Diseases, InterstitialPrognosisTomography, X-Ray Computed

Identifiers

PMID28877975
PMCPMC9488920

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.