Evidence map›Paper›PMID 28877964›Full record

ArticleJournal of neurophysiology2017

Constitutive activity of 5-HT

V M Tysseling, D A Klein, R Imhoff-Manuel, M Manuel, C J Heckman, M C Tresch

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Descending Brainstem Systems Contribute to Ankle Clonus in Humans with Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Loss of 5-HTFrontiers in neural circuits · 2025
    Article
  6. Article
  7. Myomatrix arrays for high-definition muscle recording.bioRxiv : the preprint server for biology · 2023
    Article
  8. The Involvement of CaFrontiers in neural circuits · 2021
    Article
  9. Article
  10. Article
  11. Contribution of 5-HTFrontiers in neural circuits · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

V M TysselingDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois; v-tysseling@northwestern.edu.
D A KleinDepartment of Physiology, Northwestern University, Chicago, Illinois.
R Imhoff-ManuelDepartment of Physiology, Northwestern University, Chicago, Illinois.
M ManuelDepartment of Physiology, Northwestern University, Chicago, Illinois.ORCID 0000-0002-5344-3572
C J HeckmanDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois.
M C TreschDepartment of Physiology, Northwestern University, Chicago, Illinois.
Northwestern University · US

Funding

Effect of Injury Severity and Location on Spasms Post SCIK01HD084672 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TYSSELING, VICKI M · 2015 to 2019
$653k
NICHD NIH HHS K01 HD084672
6 · The paper itself

Abstract

After spinal cord injury (SCI), reflexes become hyperexcitable, leading to debilitating muscle spasms and compromised motor function. Previous work has described adaptations in spinal systems that might underlie this hyperexcitability, including an increase in constitutively active 5-HT

Indexed as

AnimalsBaclofenFemaleFluoxetineMiceMotor NeuronsMuscle Relaxants, CentralReceptor, Serotonin, 5-HT2CReflexSelective Serotonin Reuptake InhibitorsSpinal Cord InjuriesBaclofenFluoxetineMuscle Relaxants, CentralReceptor, Serotonin, 5-HT2CSelective Serotonin Reuptake Inhibitorsmotoneuronmotor recoveryserotoninspasmsspinal cord injury

Identifiers

PMID28877964
PMCPMC5686237
OpenAlexW2750619931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.