Observational studyBMJ open2017
Daycare attendance and respiratory tract infections: a prospective birth cohort study.
Observational study in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04534036 (A 12-week Randomized, Double-Blind Controlled Trial to Evaluate the Tolerability and Gastrointestinal Response of a Novel, Multi-Strain Synbiotic), which is not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A 12-week Randomized, Double-Blind Controlled Trial to Evaluate the Tolerability and Gastrointestinal Response of a Novel, Multi-Strain Synbiotic (PDS-08™) in Children Ages 3-17
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age.The Cochrane database of systematic reviews · 2024Pooled it
- Exploring the microbial landscape of the nasopharynx in children: a systematic review of studies using next generation sequencing.Frontiers in microbiomes · 2023Pooled it
- Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections.Clinical microbiology reviews · 2019Guideline
- Multi-Strain Probiotic and Common Infections in Early Childhood Education Settings: A Randomised Controlled Trial.Journal of paediatrics and child health · 2026Trial
- Impact of social isolation due to COVID-19 on the seasonality of pediatric respiratory diseases.PloS one · 2020Trial
- Trajectories of antibiotic prescriptions in Italian children in the first four years of life: a retrospective birth-cohort study.BMC public health · 2026Article
- Streamlining protocols for the establishment of a physical biobank of respiratory viruses in the Philippines.Journal of translational medicine · 2026Article
- Incidence and severity of community acquired pneumonias in children before and after the COVID-19 pandemic.Journal of public health (Oxford, England) · 2025Article
- 'There's a Little Bit of Tension There': perspectives of mothers and early childhood educators on breast-feeding in child care centers.Public health nutrition · 2025Article
- Use of antibiotics in early life and development of diseases in childhood: nationwide registry study.BMJ medicine · 2025Article
- The impact of day care attendance on antibiotic use among children aged 0-12 years: A population-based register study.PloS one · 2025Article
- Assessing the Impact of Vitamin D Supplementation on Respiratory Infections in Children and Adolescents: A Cross-Sectional Study.Nutrients · 2024Article
- Exploring the Preventive Potential of Vitamin D against Respiratory Infections in Preschool-Age Children: A Cross-Sectional Study.Nutrients · 2024Article
- Observational
- Reduction of acute respiratory infections in day-care by non-pharmaceutical interventions: a narrative review.Frontiers in public health · 2024Review
- Controversies in Antibiotic Use for Chronic Wet Cough in Children.The Journal of pediatrics · 2024Article
- Effect of the coronavirus disease 2019 pandemic on paediatric bilateral myringotomy and tube insertion rates in New Brunswick, Canada.The Journal of laryngology and otology · 2023Article
- Impact of intrinsic and extrinsic risk factors on early-onset lung disease in cystic fibrosis.Pediatric pulmonology · 2023Article
- [Circulation dynamics of respiratory syncytial virus and its relationship with ambient temperature. 25-year series in Buenos Aires]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2023Article
- Understanding the risk of transmission of respiratory viral infections in childcare centres: protocol for the DISeases TrANsmission in ChildcarE (DISTANCE) multicentre cohort study.BMJ open respiratory research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe explored the burden of respiratory tract infections (RTIs) in young children with regard to day-care initiation.
designLongitudinal prospective birth cohort study. SETTING AND
methodsWe recruited 1827 children for follow-up until the age of 24 months collecting diary data on RTIs and daycare. Children with continuous daycare type and complete data were divided into groups of centre-based daycare (n=299), family day care (FDC) (n=245) and home care (n=350). Using repeated measures variance analyses, we analysed days per month with symptoms of respiratory tract infection, antibiotic treatments and parental absence from work for a period of 6 months prior to and 9 months after the start of daycare.
resultsWe documented a significant effect of time and type of daycare, as well as a significant interaction between them for all outcome measures. There was a rise in mean days with symptoms from 3.79 (95% CI 3.04 to 4.53) during the month preceding centre-based daycare to 10.57 (95% CI 9.35 to 11.79) at 2 months after the start of centre-based daycare, with a subsequent decrease within the following 9 months. Similar patterns with a rise and decline were observed in the use of antibiotics and parental absences. The start of FDC had weaker effects. Our findings were not changed when taking into account confounding factors.
conclusionsOur study shows the rapid increase in respiratory infections after start of daycare and a relatively fast decline in the course of time with continued daycare. It is important to support families around the beginning of daycare.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.