Evidence map›Paper›PMID 28877882›Full record

ArticleAmerican journal of physiology. Renal physiology2018

Mechanotransduction signaling in podocytes from fluid flow shear stress.

Tarak Srivastava, Hongying Dai, Daniel P Heruth, Uri S Alon, Robert E Garola, Jianping Zhou, R Scott Duncan, Ashraf El-Meanawy, Ellen T McCarthy, Ram Sharma and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Obesity-Related Glomerulosclerosis-How Adiposity Damages the Kidneys.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Prostanoid receptors in hyperfiltration-mediated glomerular injury: Novel agonists and antagonists reveal opposing roles for EP2 and EP4 receptors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  9. Review
  10. Review
  11. TAZ is important for maintenance of the integrity of podocytes.American journal of physiology. Renal physiology · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Is the kidney a target of SARS-CoV-2?American journal of physiology. Renal physiology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Tarak SrivastavaSection of Nephrology, Children's Mercy Hospital and University of Missouri at Kansas City , Kansas City, Missouri.
Hongying DaiSection of Nephrology, Children's Mercy Hospital and University of Missouri at Kansas City , Kansas City, Missouri.
Daniel P HeruthDepartment of Experimental and Translational Genetics Research, Children's Mercy Hospital and University of Missouri at Kansas City , Kansas City, Missouri.
Uri S AlonSection of Nephrology, Children's Mercy Hospital and University of Missouri at Kansas City , Kansas City, Missouri.
Robert E GarolaDepartment of Pathology and Laboratory Medicine, Children's Mercy Hospital and University of Missouri at Kansas City , Kansas City, Missouri.
Jianping ZhouRenal Research Laboratory, Research and Development, Kansas City Veterans Affairs Medical Center , Kansas City, Missouri.
R Scott DuncanDepartment of Ophthalmology, University of Missouri at Kansas City , Kansas City, Missouri.
Ashraf El-MeanawyDivision of Nephrology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Ellen T McCarthyKidney Institute, University of Kansas Medical Center , Kansas City, Kansas.
Ram SharmaRenal Research Laboratory, Research and Development, Kansas City Veterans Affairs Medical Center , Kansas City, Missouri.
Mark L JohnsonDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri at Kansas City , Kansas City, Missouri.
Virginia J SavinRenal Research Laboratory, Research and Development, Kansas City Veterans Affairs Medical Center , Kansas City, Missouri.
Mukut SharmaRenal Research Laboratory, Research and Development, Kansas City Veterans Affairs Medical Center , Kansas City, Missouri.
Children's Mercy Hospital · USUniversity of Kansas Medical Center · USUniversity of Missouri–Kansas City · USMedical College of Wisconsin · US

Funding

Transgenic and Gener-Targeting CoreP20GM104936 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN · 2012 to 2016
$10.9M
Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
Targeting PGE2 Receptors to attenuate shear stress-induced glomerular injuryR01DK107490 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI SRIVASTAVA, TARAK · 2016 to 2020
$2.0M
CYTOCHROME P-450 AND GLOMERULAR PROTEIN PERMEABILITYR01DK064969 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MCCARTHY, ELLEN T · 2005 to 2010
$1.7M
BLRD VA I01 BX001037NICHD NIH HHS U54 HD090216NIDDK NIH HHS R01 DK064969NIDDK NIH HHS R01 DK107490NIGMS NIH HHS P20 GM104936
6 · The paper itself

Abstract

Recently, we and others have found that hyperfiltration-associated increase in biomechanical forces, namely, tensile stress and fluid flow shear stress (FFSS), can directly and distinctly alter podocyte structure and function. The ultrafiltrate flow over the major processes and cell body generates FFSS to podocytes. Our previous work suggests that the cyclooxygenase-2 (COX-2)-PGE

Indexed as

Stress, MechanicalAnimalsDinoprostoneFemaleMechanotransduction, CellularMicePodocytesReceptors, Prostaglandin E, EP2 SubtypeRenal Insufficiency, ChronicSignal TransductionDinoprostoneReceptors, Prostaglandin E, EP2 Subtypeexon array analysisfluid flow shear stresshyperfiltrationmechanotransductionpodocytes

Identifiers

PMID28877882
PMCPMC5866353
OpenAlexW2753378915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.