Evidence map›Paper›PMID 28877722›Full record

ArticleBMC cancer2017

Tissue microarray analysis indicates hedgehog signaling as a potential prognostic factor in intermediate-risk prostate cancer.

Annelies Gonnissen, Sofie Isebaert, Christiaan Perneel, Chad M McKee, Clare Verrill, Richard J Bryant, Filip Van Utterbeeck, Evelyne Lerut, Karin Haustermans, Ruth J Muschel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Annelies GonnissenDepartment of Oncology, Laboratory of Experimental Radiotherapy, KU Leuven - University of Leuven, KU Leuven Campus Gasthuisberg, Herestraat 49, box 815, 3000, Leuven, Belgium.
Sofie IsebaertDepartment of Oncology, Laboratory of Experimental Radiotherapy, KU Leuven - University of Leuven, KU Leuven Campus Gasthuisberg, Herestraat 49, box 815, 3000, Leuven, Belgium. sofie.isebaert@uzleuven.be.
Christiaan PerneelDepartment of Applied Mathematics, Royal Military Academy, Brussels, Belgium.
Chad M McKeeDepartment of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.
Clare VerrillNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Richard J BryantNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Filip Van UtterbeeckDepartment of Applied Mathematics, Royal Military Academy, Brussels, Belgium.
Evelyne LerutDepartment of Pathology, University Hospitals Leuven, KU Leuven - University of Leuven, Leuven, Belgium.
Karin HaustermansDepartment of Oncology, Laboratory of Experimental Radiotherapy, KU Leuven - University of Leuven, KU Leuven Campus Gasthuisberg, Herestraat 49, box 815, 3000, Leuven, Belgium.
Ruth J MuschelDepartment of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.
KU Leuven · BECRUK/MRC Oxford Institute for Radiation Oncology · GBRoyal Military Academy · BEUniversity of Oxford · GB

Funding

Cancer Research UK 20407Medical Research Council MC_PC_12020
6 · The paper itself

Abstract

backgroundProstate cancer (PCa) is a heterogeneous disease with a variable natural history, genetics, and treatment outcome. The Hedgehog (Hh) signaling pathway is increasingly recognized as being potentially important for the development and progression of PCa. In this retrospective study, we compared the activation status of the Hh signaling pathway between benign and tumor tissue, and evaluated the clinical significance of Hh signaling in PCa.

methodsIn this tissue microarray (TMA) study, the protein expression of several Hh signaling components and Hh target proteins, along with microvessel density, were compared between benign (n = 64) and malignant (n = 170) prostate tissue, and correlated with PCa clinicopathological characteristics and biochemical recurrence (BCR).

resultsThe Hh signaling pathway appeared to be more active in PCa than in benign prostate tissue, as demonstrated by lower expression of the negative regulators PTCH1 and GLI3 in the tumor tissue compared to benign. In addition, high epithelial GLI2 expression correlated with higher pathological Gleason score. Overall, higher epithelial GLI3 expression in the tumor was shown to be an independent marker of a favorable prognosis.

conclusionHh signaling activation might reflect aggressive tumoral behavior, since high epithelial GLI2 expression positively correlates with a higher pathological Gleason score. Moreover, higher epithelial GLI3 expression is an independent marker of a more favorable prognosis.

Indexed as

Signal TransductionAgedDisease ProgressionFollow-Up StudiesHedgehog ProteinsHumansImmunohistochemistryMaleMiddle AgedModels, BiologicalNeoplasm GradingNeoplasm StagingPrognosisProstatic NeoplasmsRecurrenceSurvival AnalysisHedgehog ProteinsBiochemical recurrenceHedgehog pathwayProstate cancerTissue microarray

Identifiers

PMID28877722
PMCPMC5588741
OpenAlexW2750741153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.