Evidence map›Paper›PMID 28877711›Full record

Trial reportBMC pulmonary medicine2017

Pulmonary challenge with carbon nanoparticles induces a dose-dependent increase in circulating leukocytes in healthy males.

Marieke Berger, Johannes D de Boer, René Lutter, Michiel Makkee, Peter J Sterk, Elles M Kemper, Jaring S van der Zee

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pulmonary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Marieke BergerDepartment of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Room F-5-260, Amsterdam, The Netherlands. m.berger@amc.uva.nl.ORCID http://orcid.org/0000-0001-7047-7320
Johannes D de BoerCenter for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
René LutterDepartment of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Room F-5-260, Amsterdam, The Netherlands.
Michiel MakkeeCatalysis Engineering, Chemical Engineering, Technical University of Delft, Delft, The Netherlands.
Peter J SterkDepartment of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Room F-5-260, Amsterdam, The Netherlands.
Elles M KemperDepartment of Pharmacy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Jaring S van der ZeeDepartment of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Room F-5-260, Amsterdam, The Netherlands.
Amsterdam UMC Location University of Amsterdam · NLDelft University of Technology · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInhalation of particulate matter, as part of air pollution, is associated with increased morbidity and mortality. Nanoparticles (< 100 nm) are likely candidates for triggering inflammatory responses and activation of coagulation pathways because of their ability to enter lung cells and pass bronchial mucosa. We tested the hypothesis that bronchial segmental instillation of carbon nanoparticles causes inflammation and activation of coagulation pathways in healthy humans in vivo.

methodsThis was an investigator-initiated, randomized controlled, dose-escalation study in 26 healthy males. Participants received saline (control) in one lung segment and saline (placebo) or carbon nanoparticles 10 μg, 50 μg, or 100 μg in the contra-lateral lung. Six hours later, blood and bronchoalveolar lavage fluid (BALF) was collected for inflammation and coagulation parameters.

resultsThere was a significant dose-dependent increase in blood neutrophils (p = 0.046) after challenge with carbon nanoparticles. The individual top-dose of 100 μg showed a significant (p = 0.05) increase in terms of percentage neutrophils in blood as compared to placebo.

conclusionsThis study shows a dose-dependent effect of bronchial segmental challenge with carbon nanoparticles on circulating neutrophils of healthy volunteers. This suggests that nanoparticles in the respiratory tract induce systemic inflammation.

trial registrationDutch Trial Register no. 2976. 11 July 2011. http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2976.

Indexed as

Administration, InhalationAdultAir PollutionBronchial Provocation TestsBronchoalveolar Lavage FluidHealthy VolunteersHumansInflammationInhalation ExposureLungMaleNanoparticlesNanotubes, CarbonNeutrophilsParticle SizeParticulate MatterNanotubes, CarbonParticulate MatterAir pollutionBronchial provocation testBronchoalveolar lavageCoagulationInflammationUltrafine particles

Identifiers

PMID28877711
PMCPMC5588713
OpenAlexW2751063940

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.