ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis2018
Obesity Paradox in Patients With Deep Venous Thrombosis.
Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Association of post-thrombotic syndrome with metabolic syndrome and inflammation - a systematic review.Frontiers in immunology · 2025Pooled it
- Obesity as a Risk Factor for Venous Thromboembolism Recurrence: A Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Estrogen and obesity synergistically suppress protein S via HIF1α, enhancing thrombosis potential.The Journal of clinical investigation · 2025Article
- Real-World Patterns and Outcomes of Anticoagulation Therapy in Pulmonary Embolism: An Observational Dual-Centre Registry Analysis.Journal of cardiovascular development and disease · 2025Article
- A Retrospective Perspective: Evaluating Pulmonary Embolism Risk Factors and Survival Trends.Annals of African medicine · 2025Article
- Acute pulmonary embolism with inferior vena caval thrombus following radiofrequency ablation of the great saphenous vein despite early ultrasound surveillance.Journal of vascular surgery cases and innovative techniques · 2025Article
- Deep vein thrombosis in Ethiopia: a systematic review and meta-analysis, 2025.Thrombosis journal · 2025Review
- Impact of obesity on clinical outcomes in patients with high-risk pulmonary embolism: A comparative analysis.International journal of cardiology. Heart & vasculature · 2025Article
- Article
- Comparison of clinical indicators between perimenopausal and postmenopausal women with cardiovascular disease.Frontiers in endocrinology · 2025Article
- Prevention of deep vein thrombosis in postoperative orthopedic patients: a hybrid meta-analysis and clinical case study.Frontiers in medicine · 2025Article
- Establishment and validation of a predictive model for lower extremity deep vein thrombosis in patients with traumatic pelvic fractures.Thrombosis journal · 2024Article
- Risk factors for deep vein thrombosis of the lower extremity after total hip arthroplasty.BMC surgery · 2024Article
- Prevalence and risk factors for proximal deep vein thrombosis at admission in patients with traumatic fractures: a multicenter retrospective study.Frontiers in cardiovascular medicine · 2024Article
- Trends in prescribing and outcomes in obese versus non-obese patients receiving rivaroxaban therapy: an observational study using real-world data.European journal of clinical pharmacology · 2023Observational
- Patterns and Outcomes of Obesity Using Body Mass Index in Patients Hospitalized with Acute Cardiovascular Disorders: A Retrospective Analysis of 7284 Patients in a Middle Eastern Country.Journal of clinical medicine · 2023Article
- Management of venous thromboembolism in morbidly obese patients: a 10-year review.Journal of thrombosis and thrombolysis · 2023Article
- The use of enoxaparin as venous thromboembolism prophylaxis in bariatric surgery: A retrospective cohort study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Basic science research opportunities in thrombosis and hemostasis: Communication from the SSC of the ISTH.Journal of thrombosis and haemostasis : JTH · 2022Article
- Effective prediction model for preventing postoperative deep vein thrombosis during bladder cancer treatment.The Journal of international medical research · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to investigate the association between obesity and deep venous thrombosis (DVT) in a country with a high prevalence of obesity. This is a retrospective cohort study of patients who presented with DVT between 2008 and 2012. Data were analyzed and compared based on body mass index (BMI), and patients were classified into normal (<25), overweight (≥25 to <30), obese I (30 to <35), obese II (35 to <40), and obese III (≥40). Among 662 patients with DVT, 28% were overweight and 49% were obese. The mean age was 50.3 (16.5) years, and 51% were females. Diabetes mellitus and prior venous thromboembolism were significantly higher among obese patients. History of malignancy was more common in nonobese patients. Protein S and antithrombin III deficiency and hyperhomocysteinemia were more prevalent among morbid obese patients. Also, obese patients had higher incidence of thrombosis in the distal veins ( P = .03). Warfarin use and long-term therapy were more frequent in obese than nonobese. Postthrombotic syndrome was comparable in obese and nonobese groups. Recurrent DVT was higher in obese I ( P < .01), whereas mortality rates were greater in nonobese groups ( P = .001). Malignancy, diabetes mellitus, and common femoral vein involvement were predictors of mortality, whereas BMI ≥30 was the predictor of survival. Cox regression models showed that after adjusting for age, sex, pulmonary embolism, and duration of warfarin treatment, BMI ≥40 had better survival (hazard ratio: 0.177, 95% confidence interval: 0.045-0.691, P = .013). There is a significant association between obesity and DVT. Obese patients have characteristic risk factors and better survival. This obesity paradox needs further studies to assess its clinical and pharmacotherapeutic implications.
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